Preface The BIOTOL series of texts are designed to provide a self-study resource concerning the principles, practices and applications of biotechnology. This text is designed to explain how biotechnology may be applied to solve problems encountered in the production and use of organic chemicals in a wide range of business sectors

The BIOTOL team This series of books has been developed through a collaboration between the Open universiteit of the OPEN UNIVERSITEIT, THE NETHERLANDS Netherlands and University of Green wich (formerly Thames Polytechnic)to provide a whole Prof M C E. van Dam-Mieras library of advanced level fle rof w. H. de jeu exible learning Prof ]. de vries

9.1 Introduction 9.2 The structure, roles and abundance of sterols and steroids 9.3 Selective degradation of the sterol side chain

8. 1 Introduction 8.2 Essential and nonessential amino acid 8. 3 Stereochemistry of amino acids 8. 4 Amino acid fermentation 8.5 Recovery of the amino acid from the fermentation broth

7.1 Introduction 7. 2 Origin and composition 7.3 Exopolysaccharide structure 7. 4 Medium composition for exopolysaccharide production

6.1 An introduction to antibiotics 6. 2 General strategies for the production of antibiotics 6.3 a brief history of penicillin production 6.4 Antibacterial mode of action of B-lactam antibiotics 6.5 Biosynthesis of penicillins and cephalosporins

5.1 Introduction 5.2 Metabolic pathways and metabolic control mechanisms 5.3 The industrial production of citric acid 5.4 The production of other TCA cycle intermediates 5.5 The industrial production of itaconic acid

4.1 Introduction 4.2 Conventional protein sources 4.3 Single cell protein 4.4 Substrates for SCP production 4.5 Micro-organisms for SCP production 4.6 SCP from carbon dioxide 4.7 SCP from carbohydrates 4.8 SCP from hydrocarbons and derivatives

Efficiency of growth and product formation 3.0 Introduction 3.1 Growth stoichiometry 3.2 Relationships between product formation and growth 3.3 Determination of maintenance energy requirement and maximum biomass yield

2.1 Introduction 2.2 Micro-organisms as catalysts of organic synthesis 2.3 Enzyme preparations versus whole cell processes 2.4 Scale of production 2.5 Modes of operation of bioprocesses 2.6 Biotechnological processes verses chemical synthetic processes