IgG molncuaablndto anikgangPentamerie kN maleculee bind lo antgeon bectaral gufactonboteltacendootaple工C1g binde toasingle lgMmolecukaClg bindg to ai loest twro IgG moleculegBinding of Cigto mimyunoglobulin aclvates C1r,which cheavoaand actvaloe tha sorine prutouoe Cle
2.固有成分及激活顺序(1)识别阶段:形成C1酯酶顺序:C1q→C1r→C1s和C5转(2)活化阶段:形成C3转化酶(C4b2a)化酶(C4b2a3b)顺序:C4—→C2→C3
2.固有成分及激活顺序 (1)识别阶段: 形成C1酯酶。 顺序:C1q→C1r→C1s (2)活化阶段:形成C3转化酶(C4b2a)和C5转 化酶(C4b2a3b)。 顺序:C4→C2→C3
抗原抗体复合物C1qrsC3★C1qrs(经典途径C3转化酶)C2C4C4bC4b2aC2bC4aC3aC3bC4b2a3b(经典途径C5转化酶)补体激活经典途径
C4b2a C2b C4b2a3b
Components of the ClassicalPathwayClrClsCat+ClqC4C3C2lex
Components of the Classical Pathway C3 C4 C1 complex
Classical PathwayGeneration of C3-convertaseClrC4aC1sCa++Clq
Classical Pathway Generation of C3-convertase