FEVER CHEN SHU nfectious disease division Huashan Hospital, Fudan University
FEVER CHEN SHU Infectious Disease Division Huashan Hospital, Fudan University
Fever o Normal body temperature 口37C( set point D Circadian variation <10C: 363-37. 20C o rectal T 0.4C>oral T 0. 40C> axillary T ● Definition of fever O An elevation of core body temperature above the normal range
Fever Normal body temperature: 37oC (set point) Circadian variation <1o C ：36.3 - 37.2oC rectal T 0.4oC > oral T 0. 4oC > axillary T Definition of fever: An elevation of core body temperature above the normal range
Fever(with pyrogens) Pyrogens数热原 Elevated set-point Maintaining an abnormally elevated Temperature BMR(basal metabolic rate) increases BMR个10% =T个0.6°c T个= Elevated set-point
Fever(with pyrogens) Pyrogens 致热原 Elevated set-point Maintaining an abnormally elevated Temperature BMR(basal metabolic rate) increases T = Elevated set-point BMR 10% = T 0.6oC
PATHOGENESIS OF FEVER Antigens HYPOTHALAMUS Antigen antibody T-lymphocyte complex Bacteria and Prostaglandin E bacterial products Lymphokines Endogenous Increase in body pyrogens temperature -k(interleukin 1)-+"set point (Tumor necrosis factor) Viruses (Interferon a) Heat generation Mononuclear Heat conservation phagocyte Crystals (eg. urate) Fever
PATHOGENESIS OF FEVER
EXP Macrophage EnP hypothalamus lymphocyte Heat lossy Fever Set point个 Heat production↑
Set point↑ hypothalamus Heat loss Heat production↑ Fever ExP Macrophage lymphocyte EnP