少水子 1901 ONG UN SHANDONG UNIVERSITY 扁平苔藓 LICHED LLGDNUS Department of Oral Pathology, Shandong University
Department of Oral Pathology, Shandong University 扁平苔藓
Lichen planus 扁平苔藓( lichen Planus,LP) common cutaneomucosal diseases Wilson first report(1869) about 44% skin lichen planus associated With oral mucosa lesion Some patients the lesion only involves oral mucosa Department of Oral Pathology, Shandong University
Department of Oral Pathology, Shandong University 2 Lichen planus 扁平苔藓 (lichen Planus，LP) common cutaneomucosal diseases Wilson first report (1869) About 44% skin lichen planus associated with oral mucosa lesion Some patients the lesion only involves oral mucosa
Etiology】 Genetic predisposition H ypersensitivity to Infective agents dental materials Systemic diseases Tobacco smoking Graft-versus-host Tobacco and /or betel seases chewing Drug reactions Ⅴ itamin deficiedcies Psychiatric disorders Department of Oral Pathology, Shandong University
Department of Oral Pathology, Shandong University 3 【 Etiology 】 Genetic predisposition Infective agents Systemic diseases Graft-versus-host diseases Drug reactions Hypersensitivity to dental materials Tobacco smoking Tobacco and /or betel chewing Vitamin deficiedcies Psychiatric disorders
Etiology】 近年的研究表明,免疫调节异常与本 病的发生密切相关,特别是T细胞介导的 免疫反应对本病的发病起了重要作用。 随着疾病的进展,不仅辅助性T细 胞增多,而且抑制性T细胞也增多,但B 细胞与自然杀伤细胞很少出现。 Department of Oral Pathology, Shandong University
Department of Oral Pathology, Shandong University 近年的研究表明，免疫调节异常与本 病的发生密切相关，特别是T细胞介导的 免疫反应对本病的发病起了重要作用。 随着疾病的进展，不仅辅助性T细 胞增多, 而且抑制性T细胞也增多，但B 细胞与自然杀伤细胞很少出现。 【 Etiology 】 4
Etiology】 这表明由于T细胞被激活,产生了多 种细胞因子(如IL-4、ⅡL-6、TNF-等) 促进了T细胞介导的免疫反应过程。 T细胞功能缺陷或降低,是本病的 项客观检测标志。 Department of Oral Pathology, Shandong University
Department of Oral Pathology, Shandong University 这表明由于T细胞被激活，产生了多 种细胞因子(如IL-4、IL-6、TNF-α等)， 促进了T细胞介导的免疫反应过程。 T细胞功能缺陷或降低，是本病的一 项客观检测标志。 【 Etiology 】 5