LifecycleThe organismis transmitted bythebite of severalspeciesof blood-feedingsand flies(Phlebotomus)which carriesthepromastigote intheanteriorgutandpharynx.Itgainsaccesstomononuclearphagocytes where it transform into amastogotesand divides until the infected cell ruptures.Thereleasedorganismsinfectothercells.Thesandflyacquiresthe organisms duringtheblood meal,theamastigotestransformintoflagellatepromastigotesand multiply in thegut until theanteriorgut andpharynxarepacked.Dogsandrodentsarecommonreservoirs
11 Life cycle • The organism is transmitted by the bite of several species of blood-feeding sand flies (Phlebotomus) which carries the promastigote in the anterior gut and pharynx. It gains access to mononuclear phagocytes where it transform into amastogotes and divides until the infected cell ruptures. The released organisms infect other cells. The sandfly acquires the organisms during the blood meal, the amastigotes transform into flagellate promastigotes and multiply in the gut until the anterior gut and pharynx are packed. Dogs and rodents are common reservoirs
THE LIFECYCLE OF LEISHMANIA SPPVARIOUSFORMSOFLEISHMANIASISThe amastigotes areThe vertebrate hostreleased in theisinfectedwithvector's gut, and thepromastigotes whenparasite reproducesbitten bythe vector.as promastigotes.Thepromastigotesenter circulatingmacrophagesandreproduceasasmastigotes.Thevector (asandfly)ingestsmacrophages whenit ingests blood.The"type"ofleishmaniasisThemacrophagediesfi.e.,cutaneous.visceral,etc.the amastigotes areisdeterminedbytheprimaryreleased, and theylocationofthemacrophagesinfect more circulatingthat are infected.orfixedmacrophages(Parasites and Parasitological Resources12
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