早期发展里程碑 首次提出了初圾代谢产物Primary metabolites)和 1908 ●磺胺(su后nilamide)合成 二级代谢产物Secondary metabolites)的概念 …1891 法本公司0 GFarben) Albrecht Kosse 1886 1867 ●靛蓝(indigo)合成 毒芹碱(coniine)一首个被合成的有生理活性的生物碱 Adolf von Baeyer Albert Ladenburg 1856 ●苯胺紫(aniline purple)合成 网托品的提取分离 William Henry Perkin Johann Andreas Buchner 1850s ●甲醇、乙醇、苯，三硬酯酸甘油酯合成 Marcellin Berthelot 广物化学 水杨苷(salicin)的提取分离 1845 ●乙酸合成有机合成的概念提出 Heinrich F.G.Mein 1831 Hermann Kolbe 喇啡因的提取分离 1828 ●尿素合成 Pierre Jean Robiquet Friedrich wohler 1821 有机化学 马饯子碱、番木整碱、奎宁的提取分离 J.Caventou Pierre-J.Pelletier …1818-1820 1810 ●“生命力学说”理论提出 有市由有有有有有有中有有有有车有有有市中有有车 Jons Jacob Berzelius 单体吗啡的提取分离 1806 鲁“有机化学”这一疑念提出 Friedrich Wilhelm Adam Sertuirner --1803-4806 Jons Jacob Berzelius
天然产物化学和天然药物化学 In 1805,Current beliefs that all substances derived from plants must be acidic in nature.Serturner isolated morphine had unwittingly launched a brand-new branch of science now called "alkaloid chemistry.He was the first to isolate the active ingredient associated with a medicinal plant. OH OH HO. 0 OH Carl W.Scheele Tartaric acid.酒石酸 Louis Pasteur Morphine Friedrich Sertuirner 1742-1786 (published 1770) (1822-1895) 1783-1841 在天然产物研究的早期阶段，分离纯化手段主要是浓缩结晶与酸碱处理，因此 分离得到单体的主要是酸性或碱性化合物。在18世纪后期以Scheele.为代表的有机酸 研究，与19世纪以Serturner为起，点的生物碱研究，使得这一时期天然产物的发现呈 现出一种“由酸到碱”的大致趋势，也标志着天然药物化学的诞生
A Cell is like a Factory All life depends on a constant flow of metabolites pinocytotic vesicle mitochondrion lysosome Golgi Golgi vesicles apparatus nucleolus rough ER nucleus smooth ER. (no ribosomes) centrioles (2) Each composed of 9 microtubule triplets. ENTRY microtubules cell (plasma) membrane cytoplasm ribosome ©EM.Armstrong2001 1.Nucleus 2.Chromosomes 3.Mitochondria 4.Ribosomes 5.Chloroplasts 6.Vacuoles 7.Endoplasmic reticulum 8.Cell membrane
Nature Is A Stunning Chemical Factory OH 2 Endiandric acid C HO, HO,, 5 Cytovaricin Manzamine A Blyouyanagin A Solanoeclepin A 8 Galanthamine 9(+FR182877 12 Ajmaline 4 Abyssomic 13 Resiniferatoxir 10CP-263,114 OHOH 17 Flyanodo 8(+)-Fawcettimine (+)-Amblgulr HO 21 Trichodimerol 22 Cytovaricin 23 Zaragozic acid C 25 (-}-Lycopodine
Nature,An Excellent Synthetic Chemist OH OH H H H H HO H U T H 个 Q HO -OH 0 ONa ONa H 0==0 HO OH OH OH O OHH H 0 OH 0 OH B C D E F OH G H 52K H H N 0 OH M H OH HO OH 01 OH OH Maitotoxin刺尾鱼毒素 How Complex is the Organic Chemistry of Nature?Next?