、G蛋白耦联受体介导的 信号转导 signal transduction mediated by g protein-linked receptor)
三、G蛋白耦联受体介导的 信号转导 （signal transduction mediated by G protein-linked receptor)
神经递质与受体结合 ○神经递质 受体 腺苷酸环化酶 000 以以 (GTP GTP) (GDP cAMP G蛋白激活腺苷酸环化酶 cAMP激活蛋白激酶 蛋白激酶A
G protein- linked receptor NH2 EXTRACELLULAR SPACE CYTOSOI plasma membrane COOH 图2-1与G蛋白偶联的受体结构模式图 内而4m1
1. G protein- linked receptor
2.G protein(GTP binding protein) R ep 1 R G D step 4 p 2 ste p R日二 GT 图2-2G蛋白在信号转导中的循环
2.G protein (GTP binding protein)
3.G protein effector Adenylate cyclase, ac ☆ Phospholipase c,PLC 4 Phospholipase a2, PLA ☆ Ion channel
3.G protein effector: ❖ Adenylate cyclase, AC ❖ Phospholipase C, PLC ❖ Phospholipase A2 ,PLA2 ❖ Ion channel