Epinephrine JU M) Receptor AMPLIFICATION G protein △ Adenylyl AMPLIFICATION Cyclase □口口口口 3,,5-AMP 105M Protein AM PLIFICATION kinase具 Modified AMPLIFICATION enzyme Mletabolic produ cascade organization and amplification during signal Transduction 肾上腺素刺激下的信号放大
肾上腺素刺激下的信号放大
■信号转导有通用性、特异性 ■胞内信号转导途径相互交叉
◼ 信号转导有通用性、特异性 ◼ 胞内信号转导途径相互交叉
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细胞信号转导联盟 多个研究单位参与组成国际性的研究组织,以 “G蛋白介导和与其相关的信号转导系统”为研 究对象,不仅包括涉及G蛋白的蛋白质,还有所 有信号相关蛋白间的相互作用关系和信号通路。 对揭示生命本质,探讨疾病机制和新型药物筛选 有重大意义
细胞信号转导联盟 ◼ 多个研究单位参与组成国际性的研究组织，以 “G蛋白介导和与其相关的信号转导系统”为研 究对象，不仅包括涉及G蛋白的蛋白质，还有所 有信号相关蛋白间的相互作用关系和信号通路。 ◼ 对揭示生命本质，探讨疾病机制和新型药物筛选 有重大意义
1992: Reversible protein phosphorylation as a biological regulatory mechanism 1994: G-proteins and the role of these proteins in signal transduction in cells a 1998: Nitric oxide as a signalling molecule in the cardiovascular system 2000: Signal transduction in the nervous system a 2004: odorant receptors and the organization of the olfactory system
◼ 1992: Reversible protein phosphorylation as a biological regulatory mechanism ◼ 1994: G-proteins and the role of these proteins in signal transduction in cells ◼ 1998: Nitric oxide as a signalling molecule in the cardiovascular system ◼ 2000: Signal transduction in the nervous system ◼ 2004: odorant receptors and the organization of the olfactory system