■中和试验可分3个血清型,3型间有部分共同抗 原 ■核酸有36-52%同源性 人类是唯一的易感宿主 ■在猴肾、人胚肾等细胞可增殖,表现为细胞变 圆、坏死、脱落等典型溶细胞CPE 在猴、猩猩等灵长类动物敏感,在神经系统感 导致肢体麻痹
◼ 中和试验可分3个血清型，3型间有部分共同抗 原 ◼ 核酸有36-52%同源性 ◼ 人类是唯一的易感宿主 ◼ 在猴肾、人胚肾等细胞可增殖，表现为细胞变 圆、坏死、脱落等典型溶细胞CPE ◼ 在猴、猩猩等灵长类动物敏感，在神经系统感 染，导致肢体麻痹
Transmission Fecal- oral route(粪一口途径) via hands and objects via food and water
Transmission ◼ Fecal – oral route (粪－口途径) via hands and objects via food and water
吞入 CNS 第一次病毒血症 第二次病毒血症
A nerve which is conveyed pulse along a sensory(afferent) nerve ot (spinal) stimulus Dorsal ganglion roo neuron Axon of Skin surface sensory neuron here ganglia ry The horn of sp of the reflex, such as Ventral root a voluntary muscle where the contraction impulse is passed directly, Muscle(effector; or via interneurons, to which carry out 5 The anterior Cells of effecto neuron (such as an spinal cord organ, such as skeletal muscle alpha neuron) transmits it to
Perhaps the first written record of a virus infection consists of a heiroglyph from Memphis, drawn in approximately 1400BC, which depicts a temple priest called Siptah showing typical clinical signs of paralytic poliomyelitis
◼ Perhaps the first written record of a virus infection consists of a heiroglyph from Memphis, drawn in approximately 1400BC, which depicts a temple priest called Siptah showing typical clinical signs of paralytic poliomyelitis