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（一）文献的基本知识 ➢ 文献的概念 ➢ 文献的特征 ➢ 文献的分类 ➢ 文献的发展趋势 ➢ 关于学术期刊的基本知识
文献的特征 內部特征:学科、主题 外部特征:题名、作者、文摘、关 键词、来源或出处、参考文献等 文献的特征是文献检索的入口
文献的特征 ➢ 内部特征：学科、主题 ➢ 外部特征：题名、作者、文摘、关 键词、来源或出处、参考文献等 ➢ 文献的特征是文献检索的入口
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PMID-25405890 STAT DA-20141 DcoM-20150701 IS-1746-0921(Electronic 1746-0913( Linking) echnologies for the development of West Nile virus vaccines PG-11221-32 LID-10.217/fmb,14.67Ido11 AB-West Nile virus (WNV), an emerging mosquito-borne and zoonotic flavivirus, veterinary medicine. In recent years, severe outbreaks were observed in the USA and Europe with neighboring countries, and the virus is considered to be endemic n an increasing number of areas. Although most infections remain asymptomatic the veterinary sector, but no human vaccine s disease, which affects mostly the WNV can cause severe, even fatal, neurological elderly and immunocompromised individuals. Several vaccines have been licensed in summarizes recent strategies that are being followed to develop WNv vaccines with emphasis on technologies suitable for the use in humana FAU -Albert, Sebastian Albert s AD -Department of Immunology, Fraunhofer Inatitute for Cell Therapy 6 Immunology, Perlickstrasse 1, 04103 Leipzig, Germany FAU Sofia E AU Magnusson s eng PT- JOurnal Art⊥cle PT Rev⊥ew PL-Engl Future Microbiol uture icrobiology JID-101278120 (Weat Nile Virus Vaccines Animal MH-Europe/epidemiology Humans United states/epidemiolog West Nile Fever/*prevention s control/veterinary West Nile virus Vaccines/immunology/isolation purification lest Nile virus/*immunology OTO-NOTNIM OT-West Nile virus animal models merging virus rotective immune responses vaccine development EDAT-2014/11/1906:00 MHDA-12015/07/0206:00 cRDr-2014/11/1906:00 AID-10.2217/fmb,14,67Idoi Future Microbiol,2014:9(10):1221-32.do4:10,2217/fmb,14.67
口 Future microbiol20149(10122132.d0:10.2217/mb.1467 1. Technologies for the development of West Nile virus vaccines Ulbert s, Magnusson SE 4 Author information Abstract Nest Nile virus(WNV), an emerging mosquito-borne and zoonotic flavivirus, continues to spread worldwide and represents a major problem for human and veterinary medicine. In recent years, severe outbreaks were observed in the USa and Europe with neighboring countries, and the virus is considered to be endemic in an increasing number of areas. Although most infections remain asymptomatic, WNV can cause severe, even atal, neurological disease, which affects mostly the elderly and immunocompromised individuals. Several vaccines have been licensed in the veterinary sector, but no human vaccine is available today. This review summarizes recent strategies that are being followed to develop Wnv vaccines with emphasis on technologies suitable for the use in humans KEYWORDS: West Nile Virus; animal models; emerging virus; protective immune responses; vaccine development PMD:25405890Do:102217mb1467 [PubMed-indexed for MEDLINE] Free full text Similar articles Free article Publication Types, MeSH Terms, Substances