⊙ Meo(H2C)8 CL O Meo(H2C)8 OH (H2C)aOEt Meo(H2C)8@OI Meo 6-C4 6-D1(S)-Hydroxybernsteinsauredimethy lester aus(S) apfelsaure Meoh Meo H(onen O OH austausch) 6-DI
O MeO (H2C)8 O O O C OEt l (H2C) MeO 8 O Cl O EtOH (H2C) MeO 8 O Cl O OH Et (H2C) MeO 8 O O OEt H -H O MeO (CH2 )8 OEt O 6-C4 + O O OEt - CO2 /OEt 6-D1 (S)-Hydroxybernsteinsäuredimethylester aus (S)- Äpfelsäure HO O OH O HO MeO O OMe O H OH + (Ionenaustauscher) MeOH 6-D1
下OH OH O HO CH3OH OH HO OH O HO o HO \H Me H2O OH HO OMe OMe O HO Meo OMe OH
HO O OH O HO H HO O OH OH HO CH3OH HO O OH OH HOO Me H ~H HO O OH OH2 HOO Me HO O HO OH OMe -H2O -H HO O OMe O OH MeO O OMe O OH
6-D2 1-( Pheny lacetyl)imidazol aus Phenylessigsaure und 1. 1-Carbonyldiimidazol H 6-D2 NN NAN N-H H O N
6-D2 1-(Phenylacetyl)imidazol aus Phenylessigsäure und 1,1‘-Carbonyldiimidazol N O N O N N N N 6-D2 O O H O O H O N N N N O O + O N N N N H O O O N N N N H O O O N N N N H O N O N N O N H ~H O N O N N O N H
N FN 6-D3 Benzylethy lketon aus 1-( Pheny lacetyl)imidazol (6 D2)und Ethylmagnesiumbromid EtMgBr 6-D3 N Et- MgBr
-CO2 / - N N H O N N 6-D3 Benzylethylketon aus 1-(Phenylacetyl)imidazol (6- D2) und Ethylmagnesiumbromid O N N EtMgBr 6-D3 O O N N Et MgBr O N Et N MgBr H O NH Et N MgBr O N N H
6-D4 Fumarsaure-tert-butylethylester aus Fumarsauremonoethylester, tert-Butanol und dcc CootBu t-BuOH Etooc Etooc 6-C4 N C EtOoL H-N团 EtoOL Etooc Eto2C HN一 N=C=N H Eto2C Eto2C
6-D4 Fumarsäure-tert-butylethylester aus Fumarsäuremonoethylester, tert-Butanol und DCC N C N COOH EtOOC COOtBu EtOOC 6-C4 t-BuOH EtOOC O O N C N N N C H H EtOOC O O + EtOOC N C N O O EtO2C N HN O O H HO O O EtO2C NH O NH O O EtO2C N OH NH ~H