6_. tal stickI bent stick) Broken stick) b)E (e)Enzyme complementary to transition state 6-A
(a)No enzyme Substrate Transition state Product (metal stick) (bent stick) (broken stick) A
(b) Enzyme complementary to substrate Magnets △ △G
(e) Enzyme complementary to transition state 品品 △G1 Reaction coordinate
AG △G B uncat △G ESTEP cat S Reaction coordinate