Octameric histone core DNA H1 histone 10.nm DNA Histone octamer H1 histone Nucleosome
core histones linker DNA of nucleosome “beads-on-a-string nucleosome includes form of ch pairs of DNA NUCLEASE DIGESTS LINKER DNA released nucleosome 11 nm core particle DISSOCIATION WITH HIGH CONCENTRATION OF SALT 05 octameric 146-nucleotide-pair histone core DNA double helix DISSOCIATION ⑦6 ⑦④， 9 H2A H2B H3 H4
中国科学院上海生化与细胞所2002年招收硕士研究 生分子遗传学入学考试： 简述真核细胞内核小体与核小体核心颗粒的结构
中国科学院上海生化与细胞所2002年招收硕士研究 生分子遗传学入学考试： 简述真核细胞内核小体与核小体核心颗粒的结构
3、染色体的包装一超螺旋结构
3、染色体的包装—超螺旋结构
DNA double VVNlVvVk t2nm helix Figure 19.20 The 30 nm fiber may have a helical DNA double helix coil of 6 nucleosomes per tum,organized radially. “Beads-on 11 nm a-string Axis of coil form of chromatin 6.8:1 Nucleosome(10 nm fiber) Chromatin fiber of 30 nm packed nucleosomes 30 nm Fiber 40:1 Extended section of 300nm chromosome LoopsI 1000: Condensed section of chromosome 700nm Loops II 8000:1 Metaphase chromosome 1400nm chromosome
6.8:1 40:1 1000: 1 8000:1 DNA double helix Nucleosome (10 nm fiber) 30 nm Fiber Loops I Loops II chromosome