血的逅(续 3、神经系统的调节 直接调控,IGlc〈70-80mg/dL,情绪激动和过度兴奋 刺激交感神经或刺激延脑第四脑室,引起“糖中枢” 的反射性兴奋,经中枢传给肝脏,糖原分解补充血糖。 神经-体液的调节 4、激素调节 A. Insulin D Growth hormone(GH) B。 Adrenalin E. Glucocorticoid C. Glucagon F. Thyroxine
[血糖]的调节(续） 3、神经系统的调节 直接调控，[Glc]〈70-80 mg/dL，情绪激动和过度兴奋 刺激交感神经或刺激延脑第四脑室，引起“糖中枢” 的反射性兴奋，经中枢传给肝脏，糖原分解补充血糖。 神经-体液的调节 4、激素调节 A. Insulin B. Adrenalin C. Glucagon D. Growth hormone(GH) E. Glucocorticoid F. Thyroxine
High blood glucose Blood vessel Pancreas Insulin Low blood gl ucose Glu cago Glycogen Glycogen Glucose Glucose Pyruvate Glucose Pyruvate Muscle Livere Insulin stimulates Glucagon stimulates glucose uptake and glucose synthesis consumption and export 对
胰 岛 素 和 胰 高 血 糖 素 对 血 糖 浓 度 的 调 节
Effects of Glucagon on Blood Glucose: Production and Release of Glucose By the Liver Metabolic eFfect Effect on glucose metabolism Target enyme ↑ gen breakdown (ver) 时一p Glycogen synthesis (liver) Less glucose stored as glycogen ,③nstb Glycolysis (iver) Less glucose used as fuel in liver Ph ' Gluconeogenesis (liver) Amino acids g u0 , Pyruvate l知nae Oxaloacetate Fatty acid mobilization (adipose tissue) Less glucose used as fuel by Irve, muscle 1 Tracy glycerol lipase table 23 Effect of Insulin on Blood Glucose: Uptake of Glucose by cells and storage as Triacylglycerols and Glycogen Metabolic effect Target enzyme ↑ Glucose uptake(muscle ↑ Glucose transporter ↑ Glucose uptake(iver) ↑G| urokinase Glycogen synthesis(liver, muscle) ↑ Glycogen synthase l Glycogen breakdown(liver, muscle) L Glycogen phosphorylase T Glycolysis, acetyl-CoA production(liver, muscle) 1 Phosphofructokinase-1 T Pyruvate dehydrogenase complex T Fatty acid synthesis(liver) ↑Ace- CoA carboxyl X T Triacylglycerol synthesis (adipose tissue) ↑ Lipoprotein lipase
胰 岛 素 和 胰 高 血 糖 素 对 血 糖 浓 度 的 调 节 的 作 用 靶