The mononuclear phagocytic system consists of monocytes circulating in the blood and macrophages in the tissue Monocyte Macrophage Nucleus lysosome Nucleus Phagosome pseudopoDia Phagosome Phagosome lysosome Phagosome
lysosome lysosome Nucleus Nucleus Phagosome Monocyte Macrophage Phagosome Phagosome Phagosome Pseudopodia ➢The mononuclear phagocytic system consists of monocytes circulating in the blood and macrophages in the tissue
Macrophage --Different names in different tissues 单核细胞 Monocyte( blood) 库普弗细胞 Kupffer cells( liver) 肾小球间质细胞 Mesangial cells( kidney glomerulus 小神经胶质细胞 Microglia( brain 肺泡巨噬细胞 Alveolar macrophages(ung) 组织细胞 Histiocyte( connective tissue)
– 单核细胞 Monocyte ( blood ) – 库普弗细胞 Kupffer cells ( liver ) – 肾小球间质细胞 Mesangial cells ( kidney glomerulus ) – 小神经胶质细胞 Microglia ( brain ) – 肺泡巨噬细胞 Alveolar macrophages ( lung ) – 组织细胞 Histiocyte ( connective tissue ) Macrophage --Different names in different tissues
单核卣噬细胞 单核细胞体积较大,蹄状核(左,普通光镜)。透射电镜 显示其高尔基体发达、粒体丰富、胞浆颗粒明显(中)。 扫描电镜显示腹腔巨噬细胞粘附于玻璃表面(右
单 核 巨 噬 细 胞 单核细胞体积较大，蹄状核（左，普通光镜）。透射电镜 显示其高尔基体发达、粒体丰富、胞浆颗粒明显（中）。 扫描电镜显示腹腔巨噬细胞粘附于玻璃表面（右）
Macrophages Ingest and Degrade antigens (A) bacteria Long pseudopodia
Macrophages Ingest and Degrade antigens bacteria Long pseudopodia (A)
Macrophages Ingest and Degrade antigens (B) Puck podia 阝 acteria ssoc Phagosome Phagulysosyanve Class Il o Antigenic peptide/class II MHC Exocytosed degraded material
(B) Macrophages Ingest and Degrade antigens