下行：主要激素(CRH)与腺垂体和肾 上腺皮质进行往返联条 ①增强机体对有害刺激的抵抗力；升高血糖；抑制炎性介 质；稳定溶酶体膜；循环条统对儿茶酚胺的反应性 ②GC持续增加产生不利影响
下行：主要激素（CRH）与腺垂体和肾 上腺皮质进行往返联系 ★ ① 增强机体对有害刺激的抵抗力；升高血糖；抑制炎性介 质； 稳定溶 酶体膜； 循环系统对儿茶酚胺的反应性 ② GC持续增加产生不利影响
The Nobel Prize in Physiology or Medicine 1950 "for their discoveries relating to the hormones of the adrenal cortex,their structure and biological effects" In 1849 Thomas Addison of Scotland in 1849 discovered the connection between the adrenal glands and Addison's disease.In 1894,an English physician raised his own son's blood pressure by means of watery extracts from adrenla glands.During the early 1930's,Edward C.Kendall successfully isolated 5 different compounds from the adrenal cortex.In 1936,Thadeus Reichstein Edward Calvin Philip Showalter isolated as many as 7 substances.On April Kendall Hench 29,1948,Kendall produced a few grams of compound E.Philip S.Hench joined with Kendall at this point,and together they discovered that compound E could be successfully used to treat patients with rheumatoid arthritis.The wonder drug had finally arrived and it was christened Cortisone "cortisone"on July 1,1949.In 1950,Kendall, (A-pregnene-17c,21-diol-3,11,20-trione) Reichstein and Hench were awarded the Nobel Prize
The Nobel Prize in Physiology or Medicine 1950 “for their discoveries relating to the hormones of the adrenal cortex, their structure and biological effects” Philip Showalter Hench Edward Calvin Kendall In 1849 Thomas Addison of Scotland in 1849 discovered the connection between the adrenal glands and Addison's disease. In 1894, an English physician raised his own son's blood pre ssure by means of watery extracts from adrenla glands. During the early 1930's, Edward C. Kendall successfully isolated 5 different compounds from the adrenal cortex. In 1936, Thadeus Reichstein isolated as man y as 7 substances.On April 29, 1948, Kendall produced a f ew grams o f compound E. Philip S. Hench joined with Kendall at this point, and together they discovered that compound E could be successfully used to t reat patients with rheumatoid arthritis. The wonder drug had finally arrived and it was christened "cortisone" on July 1, 1949. In 1950, Kendall, Reichstein and Hench were awarded the Nobel Prize
生理意义：提高抵抗力 y允许作用(permissive effects) 儿茶酚胺 心血管反应 糖皮质激素 儿茶酚胺 胰高血糖素 代谢反应
生理意义：提高抵抗力 允许作用 (permissive effects) 儿茶酚胺 心血管反应 糖皮质激素 儿茶酚胺 胰高血糖素 代谢反应
糖皮质激素：有利作用 必促进蛋白质的糖异生 抑制炎性介质与细胞因子的生成与释放 》稳定溶酶体膜
糖皮质激素:有利作用 促进蛋白质的糖异生 抑制炎性介质与细胞因子的生成与释放 稳定溶酶体膜
糖皮质激素增多的不利影响： 必负氮平衡 免疫功能过低 必应激性胃粘膜病变
糖皮质激素增多的不利影响: 负 氮 平 衡 免 疫 功 能 过 低 应 激 性 胃 粘 膜 病 变