KBr OH Br H2SO4 Reaction Mixture: HBr, HSO4, KBr, K2SO4, H2O I-butanol I-bromobutane, I-butene 2-butene dibutyl ether distillation A example 1-butanol. 1-bromobutane H2SO4, KBr dibutyl ether, HO, HBr 1-Butene K,SOA. H,O 2-Butene about washing by hso purification of reaction 1-butanol 1-bromobutane dibutyl ether H,SOA. HB. product H2SO4, HBr I)washing by water 2)Washing by 10% Nac03 3)Washing by water er layer 1-bromobutane lower laver H2O I)Drying 2)Distillation Pure 1-bromobutane
OH Br KBr H2SO4 Reaction Mixture: HBr, H2SO4, KBr, K2SO4, H2O 1-butanol, 1-bromobutane, 1-butene, 2-butene, dibutyl ether distillation 1-butanol, 1-bromobutane dibutyl ether, H2O, HBr H2SO4, KBr, K2SO4, H2O 1-Butene 2-Butene Washing by H2SO4 1-bromobutane H2SO4, HBr 1) Washing by water 2) Washing by 10% NaCO3 3) Washing by water 1-bromobutane H2O 1-butanol dibutyl ether H2SO4, HBr 1) Drying 2) Distillation Pure 1-bromobutane upper layer lower layer A example about purification of reaction product
Purification COOH COOH OH OOCCH3 +(CH3CO)2O (solid) Purification by Recrystallisation Pure Product
Purification OH COOH + (CH3CO) 2 O H + OOCCH 3 COOH (solid) Purification by Rrecrystallisation Pure Product
分离纯化与色谱技术 早期的纯化方法 ◆液体物质 蒸馏( distillation)和精馏( (rectification) ◆固体物质 重结晶( recrystalization) 局限性: ◆原料需要量大,分离效率低
一、 分离纯化与色谱技术 早期的纯化方法: 液体物质 —— 蒸馏(distillation)和精馏(rectification) 固体物质 —— 重结晶(recrystalization) 局限性: 原料需要量大, 分离效率低
分离纯化与色谱技术 分析、纯化方法的发展一各种色谱技术: ◆柱色谱(CC) ◆簿层色谱(TLC) ◆离子交换色谱 ◆高效液相色谱(HPLC) 气相色谱(Gc) 优点:分析分离并用。简单易行、分离效 率高、处理童小可大
一、 分离纯化与色谱技术 分析、纯化方法的发展 —— 各种色谱技术： 柱色谱（CC） 薄层色谱（TLC） 离子交换色谱 高效液相色谱（HPLC） 气相色谱（GC） 优点：分析分离并用。简单易行、分离效 率高、处理量可小可大
Chromatograph Chromatograph is a separation process which depends on the differential distributions of the components of a mixture between a mobile bulk phase (流动相) and an essentially thin film stationary phase(固定相)
Chromatograph Chromatograph is a separation process which depends on the differential distributions of the components of a mixture between a mobile bulk phase （流动相）and an essentially thin film stationary phase（固定相）