Terminology of Hemoglobin Hemoglobins abnormal hemoglobins discovered earlier have been given letter designations Hb a: hb f, hb s More recently discovered hemoglobins have been named by the city or location of discovery Hb Constant Spring, Hb Harbin
Terminology of Hemoglobin ❖ Hemoglobins & abnormal hemoglobins discovered earlier have been given letter designations Hb A; Hb F; Hb S ❖ More recently discovered hemoglobins have been named by the city or location of discovery Hb Constant Spring; Hb Harbin
Amino acid Substitution 4 Greek letter designates affected globin chain Superscriptnumber designates affected amino acid(s) . Amino acid substitutions are denoted by the three letter abbreviation for the normally occurring amino acid followed by an arrow followed by the three letter abbreviation for the substituted amino acid
Amino Acid Substitution ❖ Greek letter designates affected globin chain ❖ Amino acid substitutions are denoted by the three letter abbreviation for the normally occurring amino acid followed by an arrow followed by the three letter abbreviation for the substituted amino acid ❖ Superscript number designates affected amino acid(s)
Pathogenesis ☆ Missense mutation
Pathogenesis ❖ Missense mutation
Missense Mutation Sickle cell disease(Hbs)
Sickle cell disease (HbS) Missense Mutation
Sickle cell disease Normal 使 Sickle cell anemia Sickle cell trait Mi
Normal Sickle Cell Disease Sickle Cell Anemia Sickle Cell Trait Mix