Medical genetics Specific(Adaptive) Immunity Specific immunity has the hallmarks of learning adapta bility and memory. The cellular component is the lymphocyte, and immunoglobulins(igs are the soluble component
Medical Genetics Specific (Adaptive) Immunity Specific immunity has the hallmarks of learning, adaptability, and memory. The cellular component is the lymphocyte, and immunoglobulins (Igs) are the soluble component
Medical genetics Immunodeficiency diseases: A group of diverse conditions caused by one or more immune system defects and characterized clinically by increased susceptibility to infections with consequent severe, acute recurrent or chronic disease
Medical Genetics Immunodeficiency diseases: A group of diverse conditions caused by one or more immune system defects and characterized clinically by increased susceptibility to infections with consequent severe, acute, recurrent, or chronic disease
Medical genetics An immunodeficiency disorder should be considered in anyone with nfections that are unusually frequent severe, and resistant, without a symptom-free interval; from an unusual organism; or with unexpected or severe complications
Medical Genetics An immunodeficiency disorder should be considered in anyone with infections that are unusually frequent, severe, and resistant; without a symptom-free interval; from an unusual organism; or with unexpected or severe complications
Medical genetics Since immunodeficiency disorders are relatively uncommon other disorders leading to recurrent nfection should be considered first If these disorders can be excluded a defect in host defense should be suspected
Medical Genetics Since immunodeficiency disorders are relatively uncommon, other disorders leading to recurrent infection should be considered first. If these disorders can be excluded, a defect in host defense should be suspected
Medical genetics DISORDERS WITH INCREASED SUSCEPTIBILITY TO UNUSUAL INFECTIONS Type of Disorder Conditions Disorder Conditions Circulatory Sickle cell disease, diabetes Primary X-linked gammaglobulin- and sys mellitus nephrosis vari in emia, DiGeorge anomaly temic cose veins, congenital deficien chronic granulomatous disorders cardiac defects cles disease, C3 deficiency Obstructive Ureteral or urethral stenosis, Unusual Antibiotic overgrowth disorders bronchial asthma. bron micro chronic infections with chiectasis, allergic rhinitis biolo OgIC resistant organism contin blocked eustachian tubes factors uous reinfection(contami cystic fibrosis nated water supply Integ Eczema. burns, skull frac infectious contact. con- mental tures. mid line sinus tracts laminated inhalation ther. defects ciliary abnormalities apy equipment) Secondary Malnutrition, prematurity Foreign Ventricular shunts, central Immuno lymphoma, splenectomy bodies venous catheter. artificial deficien uremia, immunosuppress heart valves, urinary cath cies sive therapy, protein eter, aspirated foreign losing enteropathy. bodies chronic viral diseases
Medical Genetics DISORDERS WITH INCREASED SUSCEPTIBILITY TO UNUSUAL INFECTIONS