细菌生物膜的定义 A structured community of bacterial cells enclosed in a self-producing polymeric matrix and adherent to an inert or living surface 细菌粘附—微菌落十胞外多聚物一生物膜 Bacteria/ Biofilms: A Common Cause of persistent Infections -J W Costerton, sicence 1999 p: 1318-1322 JW Costerton Center for Biofilm Engineering, Montana USA
J.W Costerton Center for Biofilm Engineering, Montana USA “ A structured community of bacterial cells enclosed in a self-producing polymeric matrix and adherent to an inert or living surface.” Bacterial Biofilms: A Common Cause of Persistent Infections - J.W Costerton，sicence 1999 p:1318-1322 细菌生物膜的定义 细菌粘附 微菌落+胞外多聚物 生物膜
Anton van 细菌生物膜的历史 Leeuwenhoek (16321723) 在物体表面形成的细菌生物膜,很久以前就观察到 dental biofilm In 1990s, the biofilm concept was introduced to the medical community, doctors began to make the connection between chronic, low-grade infections and the biofilm mode of growth 细菌生物膜-疾病的关系 Bacterial biofilm associated diseases
细菌生物膜的历史 • 在物体表面形成的细菌生物膜，很久以前就观察到 • 细菌生物膜-疾病的关系 • Bacterial biofilm associated diseases Anton van Leeuwenhoek (1632-1723) dental biofilm In 1990s, the biofilm concept was introduced to the medical community, doctors began to make the connection between chronic, low-grade infections and the biofilm mode of growth
细菌生物膜 细菌存活的有效策略藏 以多取胜 “共产主义” One for all and all for one,“人人为我,我为人人” 对抗不同的环境 Cell-Cell Communication 耐抗生素等药物的作用 >1,000倍 抵抗机体免疫因素的清除
细菌生物膜 细菌存活的有效策略 -以多取胜 - “共产主义” One for all and all for one ，“人人为我，我为人人” 对抗不同的环境 -耐抗生素等药物的作用 >1,000倍 -抵抗机体免疫因素的清除
Bacterial Biofilm Bacterial biofilms and chronic °°·0 wounds a°°。° In the biofilms there may exist multiple bacterial species
Bacterial biofilms and chronic wounds In the biofilms, there may exist multiple bacterial species Bacterial Biofilm
Nose and throat (upper respiratory system 眼结合膜 呼吸道(口腔、鼻咽腔 眼睑 Eyes(conjunctiva) 眼睫毛毛囊 Mouth 外耳 外耳道 皮肤和粘膜 不同部位 -M.种类不同 消化道 -M.数量不同 (不同部位 Large intestine 微生物来自人体、 生殖道 动物、环境 尿道开口 Urinary and genital systems 动态 生殖道外部 (lower urethra in both sexes and 阴道 vagina in females) pyright@2004 Pearson Education. Inc publishing as Benjamin Cummings
眼结合膜 呼吸道（口腔、鼻咽腔） 眼睑 眼睫毛毛囊 皮肤和粘膜 消化道 （不同部位） 生殖道 -尿道开口 -生殖道外部 -阴道 外耳 外耳道 不同部位 -M. 种类不同 -M. 数量不同 -微生物来自人体、 动物、环境 -动态