实验过程与结论 CST4 阴道高多样性的细菌状态类型(CST4)的时间持续性和所占 比例与早产相关 加德纳菌和解脲支原体的丰度可以衡量有 CST4( community state type)妇女的早产风险。 σ分娩伴随着对阴道菌群结构的极大的破坏
实验过程与结论 CST4 阴道高多样性的细菌状态类型(CST4)的时间持续性和所占 比例与早产相关 加 德 纳 菌 和 解 脲 支 原 体 的 丰 度 可 以 衡 量 有 CST4(community state type)妇女的早产风险。 分娩伴随着对阴道菌群结构的极大的破坏。 6
各部位采样结果 A Vagina Stool Saliva Tooth/ Gum p=061245- p=0.053 4.5 p=0.264 4.5 p=0068 30 1.5 1.5 15 15 0.0 10 40 10203040 10203040 10203040 B 0.6 p=0.942 0.6 p=0.637 0.6 p=0866 06 p=098 d :油 0.2 0.2 0.0 0.0 1203。401。20312。341023o C 05 p=0.314 0.5 p=0.489 0.5 p=0.581 p=0.579 0.4 04- 0.4 0.4 0.3 0.3 0.3 0.2 0.2 02- 0.2 0.1 0.1 0.0 0.0 0.0 0.0 10203040 10203040 Gestational weeks Gestational Weeks Gestational Weeks Gestational Weeks
各部位采样结果 7
5种阴道细菌状态 类型(CSTS) Very pre Term CST1 CST Lactobacillus crispatus-dominant Lactobacillus crispatus Lactobacillus iners CST2 Lactobacillus jensenii Relative Lactobacillus gasseri abundance Lactobacillus gardnerella 1000 gasseri-dominant Prevotella Prevotella CST3 Finegold- Lactobacillus Megasphaera 0.100 Atopobium iners-dominant Prevotella CST4 Ureaplasma I II lI 0010 Prevotella Lactobacillus-poor Dialister Dialister 0.001 (diverse community) Nigella CST Peptoniphilus+即 Prevotella lactobacillus Staphylococcus aureus Prevotella jensenii-dominant Sample n=761
5种阴道细菌状态 类型(CST S ) CST1 Lactobacillus crispatus -dominant CST2 Lactobacillus gasseri -dominant CST3 Lactobacillus iners -dominant CST4 Lactobacillus -poor (diverse community ) CST5 Lactobacillus jensenii -dominant n=761 8
STABILITY AND INTERCONNECTEDNESS o generally stable on the y time scale of weeks o Some maintained a single 非你非非非, CST throughout gestation whereas others exhibited relatively frequent transitions “ o The frequency of interstate transitions did not appear to be associated with delivery outcome 30 Gestational Weeks P---preterm M---marginal T---term ---delivery
STABILITY AND INTERCONNECTEDNESS Generally stable on the time scale of weeks Some maintained a single CST throughout gestation, whereas others exhibited relatively frequent transitions The frequency of interstate transitions did not appear to be associated with delivery outcome. 9 P---preterm M---marginal T---term )---delivery