组织学与胚胎学第十四章泌尿系统(2)Urinary system主讲教师：颜京霞副教授
泌 尿 系 统（2） Urinary system 主讲教师: 颜京霞 副教授 第 十 四 章 组织学与胚胎学
CapillaryAfferentarterioleEfferentarterioleEndothelialcellporeLumenofglomerularcapillaryJO2GlomerulusLumen ofBasement2glomerularmembranecapillaryBowman'scapsuleEndothelialcell3S0OrLumenofBasement1Bowman's8umembranecapsuleLumenofGVBowman'scapsuleOuterlayerofPodocyteBowman's capsule2FiltrationPodocytefootprocessslitfootprocessFiltrationInnerlayerslitofBowman'scapsuleBasement(podocytes)Omembrane.ProximalconvolutedtubuleCapillaryporeTobefiltered,asubstancemustpassthroughtheporesbetweentheendothelial cellsoftheglomerularcapillary12anacellularbasementmembrane3thefiltrationslitsbetweenthefootprocessesofthepodocytesoftheinnerlayerofBowman'scapsule@Brooks/Cole-ThomsonLearning
滤过屏障滤过膜FiltrationslitsCapillaryendotheliumPedicelsBasementmembraneFenestrationsPodocytecellbody
滤过屏障/滤过膜
(a)AnatomyoftherenalcorpuscleBloodleavesBowman'scapsuleglomerulus滤过屏障/滤过膜GlomerulusPre-urineleavesBowman'scapsule.filtration barrier血由毛细血管有孔内皮、Blood entersglomerulus.(b)Filtration管球基膜和足细胞裂孔膜构PoresinbloodvesselLargemoleculesand cells remainin bloodstream.Filtration slits成。incellsthat,OIGUGOwraparoundFluidand smallvesselsolutes are pushedthroughtheporesandthefiitration功能：对血液具有选择性slitsinto Bowman'scapsule.UnDirection of通透作用。bloodmovementD2otPearson
filtration barrier 由毛细血管有孔内皮、血 管球基膜和足细胞裂孔膜构 成。 功能：对血液具有选择性 通透作用。 滤过屏障/滤过膜
Podocyteofviscerallayerofglomerular(Bowman's)capsuleFiltration slitPedicelFenestration(pore)ofglomerularendothelial cell:preventsfiltrationofbloodcellsbutallowsallcomponentsofbloodplasmatopassthroughBasallaminaofglomerulus:prevents filtrationof largerproteinsSlitmembrane betweenpedicels:preventsfiltrationofmedium-sizedproteins