Chapter 17 Gene Regulation in Eukaryotes
Chapter 17 Gene Regulation in Eukaryotes
Similarity of regulation between eukaryotes and prokaryote 1. Principles are the same signals activators and repressors, recruitment and allostery, cooperative bind ding Expression of a gene can be regulated at the similar steps, and the initiation of transcription is the most pervasively regulated step
Similarity of regulation between eukaryotes and prokaryote 1. Principles are the same: signals, activators and repressors, recruitment and allostery, cooperative binding 2. Expression of a gene can be regulated at the similar steps, and the initiation of transcription is the most pervasively regulated step
Difference in requlation between eukaryotes and prokaryote 1. Pre-mRNA splicing adds an important step for regulation 2. The eukaryotic transcriptional machinery is more elaborate than its bacterial counterpart 3/ Nucleosomes and /their modifiers influence access to genes 4. Many eukaryotic genes have more regulatory binding sites and are controlled by more requlatory proteins than are bacterial genes
Difference in regulation between eukaryotes and prokaryote 1. Pre-mRNA splicing adds an important step for regulation. 2. The eukaryotic transcriptional machinery is more elaborate than its bacterial counterpart. 3. Nucleosomes and their modifiers influence access to genes. 4. Many eukaryotic genes have more regulatory binding sites and are controlled by more regulatory proteins than are bacterial genes
A lot more regulator bindings sites in multicellular organisms reflects the more extensive signal integration regulatory promoter Bacteria sequence Yeast Human Fg。17-1
A lot more regulator bindings sites in multicellular organisms reflects the more extensive signal integration Fig. 17-1 Bacteria Yeast Human
Enhancer: a given site binds regulator responsible for activating the gene Alternative enhancer binds different groups of regulators and control expression of the same gene at different times and laces in responsible to different signals. Activation at a distance is much more common in eukaryotes. Insulators(绝缘体 or boundary elements are regulatory sequences to ensure a linked promoter not responding to the activator binding
Enhancer: a given site binds regulator responsible for activating the gene. Alternative enhancer binds different groups of regulators and control expression of the same gene at different times and places in responsible to different signals. Activation at a distance is much more common in eukaryotes. Insulators (绝缘体) or boundary elements are regulatory sequences to ensure a linked promoter not responding to the activator binding