Genomic Organization of heavy-and light-chain segments λlight chain L1 V1 22 K light chain L1 Vk1 L2 Vk2 L3 V3 L V-40 Jx1-5 ■H==； Heavy chain L11L2M2L33 H451 Dm1-27 JH1-6 H:t0一00 1997 Current Biology Ltd./Garland Publishing.Inc
Genomic Organization of heavy- and light-chain segments
Development of the Antibody Repertoire The antibody repertoire is generated during B cell development by DNA rearrangements that combine and assemble variable-region gene segments (somatic diversification theory) Diversity is enhanced by hypermutation in mature B cells (germline theory)
Development of the Antibody Repertoire ◼ The antibody repertoire is generated during B cell development by DNA rearrangements that combine and assemble variable-region gene segments (somatic diversification theory) ◼ Diversity is enhanced by hypermutation in mature B cells (germline theory)