major determinants of myocardial oxygen consumption: > myocardial basic metabolism heart rate > contractility ventricular volume wall tensionventricr ejection time blood pressure (peripheral resistance)
major determinants of myocardial oxygen consumption: myocardial basic metabolism heart rate contractility wall tension ejection time blood pressure (peripheral resistance) ventricular volume ventricular pressure
The mechanism of antianginal drugs 02 increase supply and/or lower demand Myocardial 02 supply:Coronary blood flow, regional flow distribution Myocarial 02-demand:amount of energy required to support the work of the heart Cardiac work influenced by:heart rate, heart contractility,myocardial wall tension
The mechanism of antianginal drugs O2 increase supply and/or lower demand Myocardial O2 supply: Coronary blood flow, regional flow distribution Myocarial O2 –demand: amount of energy required to support the work of the heart Cardiac work influenced by: heart rate, heart contractility, myocardial wall tension
Section 2 Organic nitrates 1.Drugs: 口Nitroglycerin(硝酸甘油) isosorbide dinitrate(硝酸异山梨酯) 口isosorbide mononitrate(单硝酸异山梨酯)
Section 2 Organic nitrates 1.Drugs: 1.Drugs: Nitroglycerin ( Nitroglycerin (硝酸甘油) , isosorbide isosorbide dinitrate dinitrate (硝酸异山梨酯 ) isosorbide isosorbide mononitrate mononitrate (单硝酸异山梨酯 单硝酸异山梨酯 )