Through this process, will come more abundant and vastly purer antibiotics, vaccines, and yet unknown chemical and biological products to combat human disease ·通过这些过程,将会出现丰富而大量的 更纯的抗生素、疫苗、还有其他未知的 化学和生物制品,以抵抗人类疾病
• Through this process, will come more abundant and vastly purer antibiotics, vaccines, and yet unknown chemical and biological products to combat human disease. • 通过这些过程，将会出现丰富而大量的 更纯的抗生素、疫苗、还有其他未知的 化学和生物制品，以抵抗人类疾病
There are two basic technologies that drive the genetic field of drug development Recombinant dna(rDNa) Monoclonal antibody moaB) production
There are two basic technologies that drive the genetic field of drug development • Recombinant DNA (rDNA) • Monoclonal antibody (MoAB) production
2) A goal drug(目标药物) In theory,a“ goal drug” would produce the specifically desired effect be administered by the most desired route (generally orally) at minimal dosage and dosing frequency, have optimal onset and duration of activity 理论上,目标药物应能通过最理想的途径 (通常为口服)以最小的剂量和给药频率 给药,能产生特异的期望疔效,具有最理 個的起效和持续时间
2) A goal drug （目标药物） In theory, a “goal drug” • would produce the specifically desired effect, • be administered by the most desired route (generally orally) at minimal dosage and dosing frequency, • have optimal onset and duration of activity, 理论上，目标药物应能通过最理想的途径 （通常为口服）以最小的剂量和给药频率 给药，能产生特异的期望疗效，具有最理 想的起效和持续时间
exhibit no side effects, following its desired effect would be eliminated from the body efficiently, completely, and without residual effect it would be easily produced at low cost, be pharmaceutically elegant, physically and chemically stable under various conditions of use and storage (无副作用,并在发挥疗效后能完全有效地从体内消 除,且无残留效应。它应该易于生产,费用低,制 剂产品美观,在不同的使用和贮藏条件下物理和化 上稳定。)
• exhibit no side effects, • following its desired effect would be eliminated from the body efficiently, completely, and without residual effect. • it would be easily produced at low cost, • be pharmaceutically elegant, • physically and chemically stable under various conditions of use and storage. （无副作用，并在发挥疗效后能完全有效地从体内消 除，且无残留效应。它应该易于生产，费用低，制 剂产品美观，在不同的使用和贮藏条件下物理和化 学上稳定。）
3)Methods of drug discovery Most drugs are the result of carefully designed research programs of screening, molecular modification and mechanism based drug design. (大多数药物是精心设计的研究过程的结果,包 括:筛选、分子修饰和基于机制的药物设计。)
3) Methods of drug discovery • Most drugs are the result of carefully designed research programs of screening, molecular modification, and mechanismbased drug design. （大多数药物是精心设计的研究过程的结果，包 括：筛选、分子修饰和基于机制的药物设计。）