Hepatic cirrhosis: pseudolobuli 肝细胞变性坏死、纤维组织 增生及肝细胞结节状再生这 三种改变反复交替进行 解缺化假小叶形成
Hepatic cirrhosis: pseudolobule 肝细胞变性坏死、纤维组织 增生及肝细胞结节状再生这 三种改变反复交替进行
3. Functions a EXcretion bile(help the absorption of vitamin K) a Clearing the blood of particles and infections including bacteria a Synthesis: albumin, lipoproteins, coagulation factors, as well as protein C, s and antithrombin a Metabolism: protein, lipid, carbohydrate a Neutralizing and destroying drugs and toxins a Manufacturing, breaking down and regulating numerous hormones including sex hormones
3. Functions ◼ Excretion: bile (help the absorption of vitamin K) ◼ Clearing: the blood of particles and infections including bacteria ◼ Synthesis: albumin, lipoproteins, coagulation factors, as well as protein C, S and antithrombin. ◼ Metabolism: protein, lipid, carbohydrate ◼ Neutralizing and destroying drugs and toxins ◼ Manufacturing, breaking down and regulating: numerous hormones including sex hormones
Concept of Hepatic insufficiency Severe damage in liver cells result in degeneration, necrosis, fibrosis and cirrhosis, manifesting as jaundice, bleeding, infection, renal dysfunction or encephalopathy, termed all together the syndrome of Hepatic insufficiency
❖ Concept of Hepatic insufficiency Severe damage in liver cells result in degeneration, necrosis, fibrosis and cirrhosis, manifesting as jaundice, bleeding, infection, renal dysfunction or encephalopathy, termed all together the syndrome of Hepatic insufficiency 8
☆ Etiology 1. Infections: hepatitis virus(HB), bacteria, parasites 它 我国乙 肝感染 者9300 万!肝 Has Ag rates (s) 感染者 High Hepatoma 1000万! neiden areas
9 ❖Etiology 1. Infections : hepatitis virus (HBV), bacteria, parasites 我国乙 肝感染 者9300 万 !丙肝 感染者 1000万!
外膜 核心 ①结合,侵人 内质网 Dane粒 ③包装,排出 DNA (+)DNA HBsAg )DNA ④基因复非 arodOOcecDNA 转录 AAA HBSAg ③转译 AAA HBc/HBeAg 细胞核 细胞浆 Pol蛋白 X蛋白 HBV感染细胞的过程 HBV→入侵肝细胞→受染细胞表达 HbsAg、 HbeAg HBCAg→T细胞识别、致敏→杀伤受染肝细胞:清除病毒 肝细胞损伤
10 HBV →入侵肝细胞→受染细胞表达 HbsAg 、 HbeAg 、 HBcAg → T 细胞识别、致敏→杀伤受染肝细胞：清除病毒 肝细胞损伤