病因 Aetiology 三、胆汁瘀积( cholestasis) 持续肝内瘀胆或肝外胆管阻塞时,可引起原 发性或继发性胆汁性肝硬化
三、 胆汁瘀积(cholestasis) 持续肝内瘀胆或肝外胆管阻塞时，可引起原 发性或继发性胆汁性肝硬化* 。 病 因 Aetiology
o Primary biliary cirrhosis(PBC) is a chronic cholestatic liver disease involving the interlobular and septal bile ducts. This disorder is characterized by progressive inflammatory destruction of these bile ducts with the development of portal and periportal inflammation. subsequent fibrosis, and eventually cirrhosis. Portal hypertension and the consequences of end-stage liver disease can lead to early death unless effective therapy or liver transplantation intervenes
⚫ Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease involving the interlobular and septal bile ducts. This disorder is characterized by progressive inflammatory destruction of these bile ducts with the development of portal and periportal inflammation, subsequent fibrosis, and eventually cirrhosis. Portal hypertension and the consequences of end-stage liver disease can lead to early death unless effective therapy or liver transplantation intervenes
病因 Aetiology 四、循环障碍( severe heart failure) 慢性充血性心力衰竭 缩窄性心包炎 肝静脉和(或)下腔静脉阻塞 肝细胞长期瘀血缺氧、坏死和结缔组织增生 瘀血性(心源性)肝硬化
慢性充血性心力衰竭 缩窄性心包炎 肝静脉和（或）下腔静脉阻塞 肝细胞长期瘀血缺氧、坏死和结缔组织增生 瘀血性（心源性）肝硬化 四、循环障碍（severe heart failure) 病 因 Aetiology
病因 Aetiology 五、工业毒物或药物二 长期接触Cl4 磷砷等 服用双醋酚丁、甲基多巴、四环素等 中毒性肝炎 肝硬化
五、工业毒物或药物 长期接触Cl4 磷砷等 服用双醋酚丁、甲基多巴、四环素等 中毒性肝炎 肝硬化 病 因 Aetiology
病因 Aetiology 六、代谢障碍 由于遗传或先天性酶缺陷,致其代谢产物沉 积于肝,引起肝细胞坏死和结缔组织增生,如肝 豆状核变性(铜沉积)
六、代谢障碍 由于遗传或先天性酶缺陷，致其代谢产物沉 积于肝，引起肝细胞坏死和结缔组织增生，如肝 豆状核变性（铜沉积）。 病 因 Aetiology