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复旦大学附属中山医院:《内科学》课程教学资源(PPT课件,英文版)内分泌总论(高鑫)
Endocrinology (1) Roughly a hundred years ago, Starling coined the term hormone to describe secretin, a substance secreted by the small intestine into the blood stream to stimulate pancreatic secretion. In his Croonian Lectures, Starling considered the endocrine and nervous systems as two distinct mechanisms for coordination and control of organ function.
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G-protein-coupled 7-membrane- spanning receptor extracellular adenylate plasma membrane cyclase cytoplasmIc COOH tail G-protein Intracellular loop G-protein-coupled 7-membrane spanning receptor
11 G-protein-coupled 7-membrane spanning receptor
CHO CHO ACSANXPAXCOOOSOGOOOM NH Hurman B-2-Adrenergic Receptor EXTRACELLULAR SURFACE Antagonist binding ng AOAS AUGM TGCI CAVD V Y GL CIIS [RI IA oOrU G Protein Coupling HO Ro⊙R CYTOPLASMIC A0QGOSK SURFACE PKA Sites Phosphorylation Desensitization ⊙ EXKXEXXXOCXEXCXCGDED 12 G-protein-coupled 7-membrane spanning receptor
12 G-protein-coupled 7-membrane spanning receptor
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