Functions * Prosthetic group of y- Glutamic Acid carboxylase(γ谷氨酸羧化酶的辅酶), Promote synthesis of proserozyme in liver w Adjust synthesis of blood coagulation factor Ⅶ、ⅸ、Ⅹ Deficiency states ◇ Bleeding easily Source Yok(蛋黄), green color vegetables Synthesized by some entero- bacterium肠道菌合成
Functions: Prosthetic group of - Glutamic Acid carboxylase(-谷氨酸羧化酶的辅酶), Promote synthesis of proserozyme in liver. Adjust synthesis of blood coagulation factor Ⅶ、Ⅸ、Ⅹ. Deficiency states: Bleeding easily. Source: Yolk(蛋黄)，green color vegetables Synthesized by some entero-bacterium肠道菌合成
Section 2 water-soluble vitamin 1. Vitamin B1 NH2 thiamin CI CH-N CH3 米 Form TPP焦磷酸硫胺素 H3C N S CH,CH-OH w TPP is prosthetic group of pyruvic acid CHa dehydrogenase酮酸脱氢( 酶的辅基 CH2-CH2-0-P-o-P-OH OH OH 米 Catalyze a- keto acid decarboxylic reaction
Section 2. water-soluble vitamin 1. Vitamin B1 thiamin Cl - N + S CH3 CH2CH2 OH N N NH2 H3C CH2 Form TPP焦磷酸硫胺素． TPP is prosthetic group of pyruvic acid dehydrogenase 丙酮酸脱氢 酶的辅基． Catalyze α-keto acid decarboxylic reaction
H CHa active CH3-C-OH N CHb-CH-O 4严mx2 OH OH CH2-CH2-O-—P-O-P-O CHg-C-C=0 1.a-羟乙基TPP的生成 CH3-C-H TPP E Co E)一FAD FAD E 2.乙酰硫辛酰 HS. 胺的生成 NADH+H CH3-C-S 5. NADH+H FAD 的生成 E, E NAD Fadh COASH E 2 HS 3.乙酰CoA 的生成 HS 4.硫辛酰胺的生成 FAD TPP E/ E2 E3 CH3-C-SCoA
Deficiency deseases Beriberi脚气病, polyneuritis多发性神经炎 Source seeds crust and corcle(胚芽)
Deficiency deseases: •Beriberi脚气病, polyneuritis多发性神经炎 Source: seeds crust and corcle(胚芽)
2. Vitamin B2 riboflavin核黄素 ◆ Form Fmn.FAD NH ◆ prosthetic group of redox enzyme CH N FAD 2H FADH2 HCOH OH HCOH FMN 2H= FMNH2 HCOH OH OH ◆ Transfer hydogen and electron递氢与电子 LNH H C Vit B FMN AMP FAD
2. Vitamin B2 riboflavin核黄素 Form FMN, FAD prosthetic group of redox enzyme FAD + 2H = FADH2 FMN + 2H = FMNH2 Transfer hydogen and electron递氢与电子