Respiring tissue Capillary blood cO Dissolved CO2 gas 广一co2+ plasma protein+ Carbamino compounds 23% cO co2+H Hbco, Chloride shift c 70% Co2 cO+0、AH H2CO3+HCO3 +H+ 98.5% 2 O2+HHb+HbO2 +H 0 m1.5% 2 Dissolved Oz gas
Transport of oxygen a Chain β Chain a Forms of oxygen transported Chemical combination: 98.5% Physical dissolution: 1.5% Fe+t atom Porphyrin molecule ■ Hemoglobin(血红蛋白,Hb) is essential for the transport of O2 by blood
Transport of oxygen ◼ Forms of oxygen transported – Chemical combination: 98.5% – Physical dissolution: 1.5% ◼ Hemoglobin (血红蛋白，Hb) is essential for the transport of O2 by blood
Normal adult hemoglobin is composed of four subunits linked together, with each subunit containing a single heme --the ring-like structure with a central iron atom that binds to an oxygen atom
◼ Normal adult hemoglobin is composed of four subunits linked together, with each subunit containing a single heme -- the ring-like structure with a central iron atom that binds to an oxygen atom
CH=CH. CH CH N N一Fe—N N CH C C CH=CH CH CH CH 3 N CH O Globin polypeptide Hemoglobin is the gas-transport molecule inside erythrocytes Oxygen binds to the iron atom. Heme attaches to a polypeptide chain subunits bind to each other to make a single hemoglobin molecule o by a nitrogen atom to form one subunit of hemoglobin. Four of thes
Hemoglobin is the gas-transport molecule inside erythrocytes. Oxygen binds to the iron atom. Heme attaches to a polypeptide chain by a nitrogen atom to form one subunit of hemoglobin. Four of these subunits bind to each other to make a single hemoglobin molecule
Two forms of hb a Deoxygenated state(deoxyhemoglobin) when it has no oxygen a Oxygenated form(oxyhemoglobin carrying a full load of four oxygen
Two forms of Hb ◼ Deoxygenated state (deoxyhemoglobin) -- when it has no oxygen ◼ Oxygenated form (oxyhemoglobin) -- carrying a full load of four oxygen