Cell signal transduction diseases moon rover Zhao Mingyao BMC. ZZU
Cell signal transduction & diseases Zhao Mingyao BMC. ZZU moon rover
cell signal transduction ce specific response signal Proliferation Differentiation Metabolism unction Stress Apoptosis ↑ or l or loss→ disease
signal cell specific response Proliferation Differentiation Metabolism Function Stress Apoptosis cell signal transduction or or loss → disease
Survival Factors Transmitters rowth Factors (e.g, IGF1) (e.g. interleukins, l (e.g. TGFa, EGF Extracellular Matrix RTK cdc42 Wnt PLC Grb2/SOS Fyn/shc PI3K G-Protein Dishevelled 4 PKCI Adenylate GSK 3B PKA Cytokines IKB MEKK MAPK MKK enin (e.g, EPC) JAKs STAT3,5 Bcl-xL Myc: -Mad: ERK JNKs B-catenin: TCF Max -Max Cytochrome C CREB CyclID-p16IGI RbY CDK4 Caspase 9 Gene Requlation Caspase 8 ApoptosIS *CyclE +p27 ARF FADD mdm2 Bcl-2 Proliferation normality Bim
1. Signal constitution site feature (1 )Extracellu Chemical: lipid-soluble water-soluble ar Physical: mechanical, light, electrical (2)Intracellul Enzyme, protein, ion, lipid ar a
1. Signal constitution site feature (1)Extracellu lar ~ (2)Intracellul ar ~ Chemical: lipid-soluble & water-soluble Physical: mechanical, light, electrical Enzyme, protein, ion, lipid