Starling forces Involved in Filtration What forces favor/oppose filtration
Starling Forces Involved in Filtration: What forces favor/oppose filtration?
Glomerular filtration · Mechanisn: Bulk flov Direction of movement: From glomerular capillaries to capsule space Driving force: Pressure gradient(net filtration pressure, NFP) T ypes of pressure Favoring Force: Capillary blood Pressure(BP) Opposing Force: Blood colloid osmotic pressure(cop) and Capsule Pressure(Cp)
Glomerular filtration • Mechanism: Bulk flow • Direction of movement : From glomerular capillaries to capsule space • Driving force: Pressure gradient (net filtration pressure, NFP) • Types of pressure: Favoring Force: Capillary Blood Pressure (BP), Opposing Force: Blood colloid osmotic pressure(COP) and Capsule Pressure (CP)
BP 60 out 10 out COP 32 in NFP CP 18 in Capillary blood pressure(BP) 60 mmHg out Colloid osmotic pressure(CoP) -32 mmHg in Capsular pressure(CP) 18 mmHg in Net filtration pressure( NFP) 10 mmHg out
Glomerular filtration Pores in endothelium Glomerulus Pedicels Lamina of podocytes densa Filtration slit Capsular space Filtration slit Ble lood Plasma protein Small sol Filtration pressur particles 10 mm Hg Filtrate in capsular space
Glomerular Filtration
Glomerular filtration rate(GFr) Amount of filtrate produced in the kidneys each minute. 125mL/min= 180L/day Factors that alter filtration pressure change GFR These include Increased renal blood flow -Increased GFR Decreased plasma protein - Increased GFR. Causes edema Hemorrhage - Decreased capillary bp- Decreased GFR Capsular pressure
• Amount of filtrate produced in the kidneys each minute. 125mL/min = 180L/day • Factors that alter filtration pressure change GFR. These include: – Increased renal blood flow -- Increased GFR – Decreased plasma protein -- Increased GFR. Causes edema. – Hemorrhage -- Decreased capillary BP -- Decreased GFR – Capsular pressure Glomerular filtration rate (GFR)