Excretion Loss of fluid from body in form of urine Amount= Amount + Amount Amount of Solute Filtered Secreted Reabsorbed Excreted
Excretion: – Loss of fluid from body in form of urine Amount = Amount + Amount -- Amount of Solute Filtered Secreted Reabsorbed Excreted
Glomerular filtration
Glomerular filtration
Glomerular filtration blood enters glomerular capillary filters out of renal corpuscle large proteins and cells stay behind everything else is filtered into nephron glomerular filtrate plasma like fluid Glomerular capsule Vascular Parietal layer Capsular space Afferent Podocytes of arteriole visceral layer Glomerular capillar B|ood→ flo Proximal convolu Efferent tubule arteriole Urinary Blood
– blood enters glomerular capillary – filters out of renal corpuscle • large proteins and cells stay behind • everything else is filtered into nephron • glomerular filtrate – plasma like fluid Glomerular filtration
Factors that determining the glumerular filterability Molecular weight Charges of the molecule
Factors that determining the glumerular filterability ⚫ Molecular weight ⚫ Charges of the molecule
Filtration membrane -One layer of glomerular capillary cells Fenestration,70-90 nm, permeable to protein of small molecular capillary F P fenestration BM- S BM: basal P BM membrane E BM podocytes FS: filtration slit 10
Filtration Membrane –One layer of glomerular capillary cells. –Fenestration, 70 – 90 nm, permeable to protein of small molecular C: capillary F: fenestration BM: basal membrane P podocytes FS: filtration slit