Anatomy of Kidney Cortical nephron ■80%-90 glomeruli in outer cortex ■ short loops of henle extend only short distance into medulla blood flow through cortex is rapid cortical interstitial fluid 300 mOsmolar
Anatomy of Kidney ◼ Cortical nephron ◼ 80%-90% ◼ glomeruli in outer cortex ◼ short loops of Henle ◼ extend only short distance into medulla ◼ blood flow through cortex is rapid ◼ cortical interstitial fluid 300 mOsmolar
Anatomy of Kidney o Juxtamedullary nephron glomeruli in inner part of cortex long loops of Henle extend deeply into medulla blood flow through vasa recta in medulla is SlOW medullary interstitial fluid is hyperosmotic maintains osmolality, filtering blood and maintaining acid-base balance
Anatomy of Kidney ⚫ Juxtamedullary nephron – glomeruli in inner part of cortex – long loops of Henle ⚫ extend deeply into medulla. – blood flow through vasa recta in medulla is slow – medullary interstitial fluid is hyperosmotic – maintains osmolality, filtering blood and maintaining acid-base balance
2. The juxtaglomerular apparatus Including macula densa, extraglumerular mesangial cells, and juxtaglomerular (granular cells) cells Efferent 92001 BrooksCole.Thomson Learning Lumen of Endothelial Bowmans capsule Distal tubule Smooth Bowmans capsule Efferent arteriole capillaries Afferent arteriole acu densa Podocyte Granular cells Distal tubule Afferent arteriole
2. The juxtaglomerular apparatus Including macula densa, extraglumerular mesangial cells, and juxtaglomerular (granular cells) cells
3. Characteristics of the 18 mm Hg renal blood flow mm Hg 1. High blood flow. 1200 ml/min or 21 percent of mm Hg the cardiac output. 949 10 mm Hg 13 mm H to the cortex n Hg 2, Two capillary beds High hydrostatic pressure in glomerular capillary (about 60 mmHg) and Interstitial fluid low hydrostatic pressure pressure 6 mm Hg in peritubular capillaries Ⅴ esa recta 0 mm Hg (about 13 mmHg)
3. Characteristics of the renal blood flow: 1, High blood flow. 1200 ml/min, or 21 percent of the cardiac output. 94% to the cortex 2, Two capillary beds High hydrostatic pressure in glomerular capillary (about 60 mmHg) and low hydrostatic pressure in peritubular capillaries Vesa Recta (about 13 mmHg)
Blood flow in kidneys and other organs rgan Approx blood flow A-VO difference (mg/min/g of tissue) (mI/L) Kidney 4.00 12-15 depends on reabsorption of Heart 0.80 96 Brain 0.50 48 Skeletal muscle 0.05 (rest Skeletal muscle 1.00 (max. exercise)
Blood flow in kidneys and other organs Organ Approx. blood flow (mg/min/g of tissue) A-V O2 difference (ml/L) Kidney 4.00 12-15 (depends on reabsorption of Na+ ) Heart 0.80 96 Brain 0.50 48 Skeletal muscle (rest) 0.05 - Skeletal muscle (max. exercise) 1.00 -