Section 1:RAAS inhibitors ACE Inhibitors in Heart Failure angiotensinogen blood normal kidney renin hypertension pressure angiotensin I 3WNTOA plasma myocardial volume angiotensin converting dysfunction, moderate enzyme(ACE) myocardial dysfunction, aldosterone angiotensin ll severe OUTFLOW RESISTANCE adrenal gland blood vasoconstriction pressure
Section 1: RAAS inhibitors Section 1: RAAS inhibitors ACE Inhibitors in Heart Failure ACE Inhibitors in Heart Failure
Mechanism of Action of ACEI ●Afterload reduction ●Preload reduction Reduction of facilitation of sympathetic nervous system o Reduction of cardiac hypertrophy Drugs of choice in heart failure (with diuretics) Current investigational use:Acute myocardial infarction
Mechanism of Action Mechanism of Action of ACEI of ACEI Afterload reduction Preload reduction Reduction of facilitation of sympathetic nervous system Reduction of cardiac hypertrophy Drugs of choice in heart failure (with diuretics) Current investigational use: Acute myocardial infarction
Aldosterone antagonist Spironolactone Aldosterone antagonist,K-sparing diuretic Prevention of aldosterone effects on: Kidney Heart? Aldosterone inappropriately elevated in CHF Mobilizes edema fluid in heart failure Prevention of hypokalemia induced by loop diuretics (protection against digitalis toxicity?) Prolongs life in CHF patients
Aldosterone Aldosterone antagonist antagonist Aldosterone antagonist, K-sparing diuretic Prevention of aldosterone effects on: – Kidney – Heart? Aldosterone inappropriately elevated in CHF Mobilizes edema fluid in heart failure Prevention of hypokalemia induced by loop diuretics (protection against digitalis toxicity?) Prolongs life in CHF patients Spironolactone Spironolactone
Section 2:Diuretics hydrochlorothiazide Mechanism of Action in Heart Failure Preload reduction:reduction of excess plasma volume and edema fluid o Afterload reduction:lowered blood pressure
Section 2: Section 2: Diuretics Diuretics Preload reduction: reduction of excess plasma volume and edema fluid Afterload reduction: lowered blood pressure Mechanism of Action in Heart Failure Mechanism of Action in Heart Failure hydrochlorothiazide
Section 3 B-Adrenoceptor blockers Mechanism of action: 1.Antagonize the sympathetic nerve activity ①↓damage on cardiac muscle from CA ②↓renin,↓RAS,↓cardiac load ③↑B-R,come back the transmit ability ④↑sensitivity of B-R to catecholamines 2.Antioxidation blocking a-R carvedilol 3.Antiarrhythmia and improve myocardial ischemia
Section 3 Section 3 β-Adrenoceptor Adrenoceptor blockers blockers Mechanism of action: 1. Antagonize the sympathetic nerve activity ①↓damage on cardiac muscle from CA ②↓renin , ↓RAS，↓ cardiac load ③↑β-R，come back the transmit ability ④↑sensitivity of β-R to catecholamines 2. Antioxidation , blocking α1 -R — carvedilol 3. Antiarrhythmia and improve myocardial ischemia