Membrane proteins and lipids can be confined to s specific domain lipid raft
2. Singer and Nicolson's model of membrane structure: The fluid-mosaic model is the central dogma"of membrane biology. A. The core lipid bilayer exists in a fluid state, capable of dynamic movement. B Membrane proteins form a mosaic of particles penetrating the lipid to varying degrees. (outside of cell) membrane protein The fluid mosaic glycoprotein Model, proposed in cholesterol 1972 by Singer and phospholipid Nicolson had two key features, both plasma implied in its name. (cytoplasm inside of cell
2. Singer and Nicolson’s Model of membrane structure: The fluid-mosaic model is the “central dogma” of membrane biology. A. The core lipid bilayer exists in a fluid state, capable of dynamic movement. B. Membrane proteins form a mosaic of particles penetrating the lipid to varying degrees. The Fluid Mosaic Model, proposed in 1972 by Singer and Nicolson, had two key features, both implied in its name
Carbohydrate chains Phospholipid Lipid-anchored membran Hydrophobic Plasma Hydrophilic Carbohydrate Integral chains membrane Peripheral nembrane Outer membrane Phospholipid (a)Fluid mosaic model of membrane b layer (7-nm) Phospholipid surface transmembrane NH, amino acids carbohydrate (b) An integral membrane protein c)An enlarged helical transmembrane segment glycoprotein) (20-30 amino acids)
3. The chemical composition of membranes A Membrane Lipids: The Fluid Part of the model o Membrane lipids are amphipathic. There are three major classes of lipids Phospholipids: Phosphoglyceride and sphingolipids Glycolipids Sterols( is only found in animals)
3. The chemical composition of membranes A. Membrane Lipids: The Fluid Part of the Model Phospholipids: Phosphoglyceride and sphingolipids Glycolipids Sterols ( is only found in animals) ❖Membrane lipids are amphipathic. ❖There are three major classes of lipids:
Composition of biomembrane Cell surface PM p Golgi Cytosol I ER ER 0000 Lumen Cholesterol PO Glycolipid PE SM○