Immune non mmune initiation end stage Primary GN
immune non-immune initiation end stage Primary GN
Sites of pathological changes Mesangium Mesangial cell Mesangial matrix Basement membrane Podocyte Foot process Endothelial cell
Sites of pathological changes Mesangium Mesangial cell Mesangial matrix Basement membrane Podocyte Foot process Endothelial cell
Glomerular basement Podocyte membrane aaaa Foot processes The peripheral Capillary portion of a glomerular Mesangial Capillary angle endothelium lobule Microfilaments Gesang ur Mesangial matrx
The peripheral portion of a glomerular lobule
Pathological changes LM Mesangial cells, matrix of mesangium Epithelial cells Endothelial cells Basement membrane Loops of glomeruli EM Foot process Basement membrane Hyperplasy of mesangium (electron-dense deposits F Sites, appearances and types of the deposit (g or c)
Pathological changes • LM – Mesangial cells, matrix of mesangium – Epithelial cells – Endothelial cells – Basement membrane – Loops of glomeruli • EM – Foot process – Basement membrane – Hyperplasy of mesangium (electron-dense deposits ) • IF – Sites, appearances and types of the deposit (Ig or C)
Basical changes e Proliferation Fibrosis and sclerosis Necrosis Infiltration of inflammatory cells
Basical changes •Proliferation •Fibrosis and sclerosis •Necrosis •Infiltration of inflammatory cells