DAI的收录范围 WISALNPACSANNAMIM ALI DAI共收录世界600多所大学的学 位论文,年报道量约5万篇。在A辑和B 辑中的报道文摘的原文可从UM或各授 予单位获取。C辑中的报道文摘多数论 文从UMI是得不到的,只能从各授予单 位获取
DAI的收录范围 DAI共收录世界600多所大学的学 位论文，年报道量约5万篇。在A辑和B 辑中的报道文摘的原文可从UMI或各授 予单位获取。 C辑中的报道文摘多数论 文从UMI是得不到的，只能从各授予单 位获取
DAI的编排结构 DAI各分册的结构是一样的,条 目按照主题编排。主题类目列在每 辑的“导言”页上。在每一个类 目或子类目中,条目按照作者姓名 字顺排列
DAI的编排结构 DAI各分册的结构是一样的，条 目按照主题编排。主题类目列在每 一辑的“导言”页上。在每一个类 目或子类目中，条目按照作者姓名 字顺排列
DA的著录格式(-) 条目的上方是有关论文的书目信息, 然后是文摘正文。每一个条目包括的基 本信息有:论文题目、著者姓名、学位 及获得时间、授予学位的机构、原文页 数、论文导师、UM索取号码
DAI的著录格式（一） 条目的上方是有关论文的书目信息， 然后是文摘正文。每一个条目包括的基 本信息有：论文题目、著者姓名、学位 及获得时间、授予学位的机构、原文页 数、论文导师、UMI索取号码
DA的著录格式(二) Genetic and cytological analyses of four partial sterile mutants in soy bean. ① Pereira, Telma Nair s,②phD③ lowa State University,④ 1994.⑤187pp.⑥ Major professor: Reid g Palmer⑦ Order no.DA8205860⑧ ( abstracts)⑨ ①论文题目②著者姓名③学位名称④机构名 ⑤授予时间⑥论文页数⑦导师姓名⑧订购号 ⑨文摘
DAI的著录格式（二） Genetic and cytological analyses of four partial – sterile mutants in soybean. ① Pereira, Telma Nair S., ②ph. D ③ Iowa State University, ④ 1994. ⑤ 187pp. ⑥ Major Professor: Reid G. Palmer ⑦ Order No. DA8205860 ⑧ (abstracts) ⑨ ① 论文题目②著者姓名③ 学位名称 ④ 机构名 ⑤ 授予时间⑥ 论文页数 ⑦导师姓名 ⑧ 订购号 ⑨ 文摘
regm to gorps: Role of the Na+/H+ exchanger in ation intracellular pH. McLean, Lee Anne, Ph D. Uni- y of Califomia, Davis, 1999. 222pp Adviser: Peter M. Cala Order Number DA9948717 The goal of my dissertation was to evaluate the role of the Na/H i exchanger(NHE in the regulation of intracellular pH(pH;) in malignant gliomas. The ubiquitous NHEI isoform is upregulated in gliom as aa demon strated by an alkaline shift in pH dependence compared to normal astro- cytes. The importance of NHE to gliomas was demonstrated by inhibi- tion studieS, which reeulted in pronounced acidification and cell death of gliomas with little effect on normal astrocytes. The elevated pH: and e hanced NHEl activity was not the result of a mutant NHE isoform in the 文 netic mutations may he involved in the pat hogen esis of gliomas, including many steps in the growth factor signaling cascade, activation of NHEl with corresponding intracellular alkalinization is a common feature of moat of these tumors. This common phenotype makes the exchanger an attractive target for a tumcr-selective therapy that should be effective regardless of the initial cause of the tumor pathogenesis To further my understanding of NIE function and regulation, I utilized the Amphiuma red blood cell(RBC) model system that haa been well char- acterized by the Cala laboratory. The Amphizma(ak a. gorp")NHE is an attractive model due to its high abundance, low tonic activity, and ro- bust response to both acidification and cell shrinkage, with kinetics that are remarkably similar to human NHEl (hNHE1). The structure of the Amphs uma exchanger (atNHE1) is also highly homologous to hNHEl, with 79%6 identity and 89% similarity at the amino acid level. Furthermore, the pro- poBed ion tranaport regions (M6-M7), inhibitor binding eitcs, and known regulatory dom ains are highly conserved between these two isoforms. Most importantly, the fact that the cloned at NHEI protein is able to function in both PH and volume regulatory capacities, similar to that seen in native Amphauma RBCB, indicatea that the regulatory control mechanisms must be conserved between the two systems as well. Despite this remarkable homology, I found some significant functional differences between the hu- man and Amp hium a exchangers which will provide further insight into the structure/function relationships of thie ubiquitously expressed transporter
DAI 文摘样例