Ach is the natural nical chem Related compounds are agonist at the useful in the neuroscience neuromuscular research unction O CH3 Carbachol and related CH3 compounds are used o Tubocurarine and other, clinically for Gl disorders, CH related compounds glaucoma, salivary gland malfunction, etc CHa are used to paralyze muscles auring surgery. CH3 OCH NH2-C-OCH2CH2-N--CH3 OH H H Carbachol CH3O OH H3C H D-Tubocurarine
16 Clinical Chemistry Ach is the natural agonist at the neuromuscular junction. Tubocurarine is the primary paralytic ingredient in curare. Tubocurarine competes with ACh for binding to receptor- but does not open the pore. So tubocurarine is a neuromuscular blocking agent. Tubocurarine and other, related compounds are used to paralyze muscles during surgery. Carbachol is a synthetic agonist not hydrolyzed by acetylcholinesterase. Carbachol and related compounds are used clinically for GI disorders, glaucoma, salivary gland malfunction, etc. Suberyldicholine is a synthetic neuromuscular agonist. Related compounds are useful in the neuroscience research
Anticholinesterase Agents Anticholinesterase(anti-ChE胆碱酯酶抑制剂) agents inhibit acetylcholinesterase(乙酰胆 碱酯酶) >prolong excitation at the Nmj
17 Anticholinesterase Agents ➢Anticholinesterase (anti-ChE 胆碱酯酶抑制剂) agents inhibit acetylcholinesterase （乙酰胆 碱酯酶） ➢prolong excitation at the NMJ
Anticholinesterase Agents 1. normal. ACh Choline acetate AChe 2. With anti-ache ACh Choline Acetate anti-achE
18 1. Normal: ACh Choline + Acetate AChE 2. With anti - AchE: ACh Choline + Acetate anti - AChE Anticholinesterase Agents
Uses of anti-ChE agents > Clinical applications( Neostigmine,新斯的明, Physostigmine毒扁豆碱) ≯ insecticides( organophosphate有机磷酸酯) Nerve gas(eg. Sarin沙林,甲氟膦酸异丙酯。 种用作神经性毒气的化学剂)
19 Uses of anti-ChE agents ➢Clinical applications (Neostigmine, 新斯的明, Physostigmine毒扁豆碱) ➢Insecticides (organophosphate 有机磷酸酯) ➢Nerve gas (e.g. Sarin 沙林，甲氟膦酸异丙酯。一 种用作神经性毒气的化学剂))
②8 POLICE HEADQUARTERS, 50560 BUKIT AMAN, KUALA LUMPUR TELEPHONE:0322668311122668320122668321FAX:0322668330 MEDIA STATEMENT: INSPECTOR GENERAL OF POLICE DEATH OF KOREAN NATIONAL PRELIMINARY ANALYSIS REPORT FROM THE CHEMISTRY DEPARTMENT OF MALAYSIA THE ROYAL MALAYSIA POLICE(RMP) HAS RECEIVED THE PRELIMINARY REPORT FROM THE CHEMISTRY DEPARTMENT OF MALAYSIA. WITH REGARDS TO THE DEATH OF A NORTH KOREAN NATIONAL RECENTLY THE CENTRE FOR CHEMICAL WEAPONS ANALYSIS OF THE DEPARTMENT HAS CARRIED OUT PRELIMINARY ANALYSIS INVOLVING 1. DRY SWAB- EYE MUCOSA VX NERVE AGENT 2. DRY SWAB- FACE THE CHEMICAL SUBSTANCE ON THE EXIHIBITS HAS BEEN IDENTIFIED AS ETHYL S-2-DIISOPROPYLAMINOETHYL METHYLPHOSPHONOTHIOLATE OR"VX NERVE AGENT
VX NERVE AGENT