B Bone marrow response 1. Regenerative a Bone marrow actively responds by increasing its production of RBCS b Findings: (1)Polychromasia (2) Reticulocytosis
B. Bone marrow response 1. Regenerative a. Bone marrow actively responds by increasing its production of RBC’s. b. Findings: (1) Polychromasia. (2) Reticulocytosis
(3)Macrocytosis (increased MCV) and hypochromia associated with reticulocytosis. (4)Hypercellular bone marrow with a low M/E ratio (5)Increase in MCV and RDW
. (3) Macrocytosis (increased MCV) and hypochromia associated with reticulocytosis. (4) Hypercellular bone marrow with a low M/E ratio. (5) Increase in MCV and RDW
C. The presence of regeneration suggests an extramarrow cause. (1)Blood loss (2)Erythrocyte destruction (hemolysis) d Bone marrow examination would reveal erythropoietic hyperplasia
c. The presence of regeneration suggests an extramarrow cause. (1) Blood loss (2) Erythrocyte destruction (hemolysis) d. Bone marrow examination would reveal erythropoietic hyperplasia
2. Non-Regenerative a Inadequate bone marrow response because of a bone marrow disorder b Polychromasia and reticulocytosis are absent
2. Non-Regenerative a. Inadequate bone marrow response because of a bone marrow disorder. b. Polychromasia and reticulocytosis are absent. •
C Pathophysiologic mechanism 1.Blood loss-hemorrhagic anemia 2. Accelerated erythrocyte destruction-hemolytic anemia 3 Reduced or defective erythropoiesis
C. Pathophysiologic mechanism 1.Blood loss–hemorrhagic anemia. 2. Accelerated erythrocyte destruction–hemolytic anemia. 3. Reduced or defective erythropoiesis