Single alveolur Aqueous layer Lamellar body (stores surfactant) Alveolar macrophage cO type l pneumocyte Capillary Type I lining
肺表面张力 液体薄层 肺泡腔 液面压力 表面张力
表面张力 液体薄层 肺泡腔 液面压力 肺表面张力
1. Etiology and mechanism nypoxIa、 acidosis Permeability of capillary Lung edema, exudation of plasma protein hyaline membrane
1. Etiology and mechanism hypoxia、acidosis ↑permeability of capillary Lung edema、exudation of plasma protein hyaline membrane
Normal Alveolus Injured Alveolus during the Acute Phase Alveolar air space Protein-rich edema fluid loughing of bronchial epithelium Necrotic or apoptotic type I cell Inactivated surfactant Epithelial Red cell Interstitium Type ll cell intact type ll cell Aleolar PAF macrophage Proteas ellul Denuded TNF-cE basement membrane Hyaline membrane leola Migrating neutrophil Widened Surfactant layer edematous interstitium collagen basement Platelets Neutrophil Capillary Red cell Swollen, injured endothelial cells Fibroblast Fibroblast
manifestation distress in 6 hours after birth tachypnea, dyspnea groan(呻吟)、 three depressions sing(吸凹) cyanosis, decrease of breathing sound respiratory feilure progressive distress
2、manifestation distress in 6 hours after birth tachypnea, dyspnea groan(呻吟)、three depressions sing(吸凹) cyanosis、decrease of breathing sound respiratory feilure progressive distress