Derivation ar diseases 2pg 4 2 .o The number of heterozygote carriers in the population is much larger than the affected The ratio increases as the disease frequency decreases
2pq q 2 ≈ 2q q 2 ＝ 2 q ❖ The number of heterozygote carriers in the population is much larger than the affected. ❖ The ratio increases as the disease frequency decreases. Derivation AR diseases
Derivation Xd diseases 1 1 1 1 p+2p+27p+21-m=2-p°-2 The ratio of affected females to the males is approximately 2 to 1
p p 2 ＋2pq ≈ 1 2 ＝ 1 p ＋ 2q ＝ 1 p ＋ 2(1－p) ＝ 1 2－p ❖ The ratio of affected females to the males is approximately 2 to 1. Derivation XD diseases
Derivation XR diseases q q q .o More affected males than affected females The ratio increases as the disease frequency decreases
❖ The ratio increases as the disease frequency decreases. q q 2 ＝ 1 q ❖ More affected males than affected females Derivation XR diseases