Hepatitis a Prevention Immune Globulin ■Pre- exposure travelers to intermediate and high HAV-endemic regions Post-exposure(within 14 days) Routine household and other intimate contacts Selected situations institutions(e.g, day care centers common source exposure(e.g,, food prepared by infected food handler
◼ Pre-exposure ◼ travelers to intermediate and high HAV-endemic regions ◼ Post-exposure (within 14 days) Routine ◼ household and other intimate contacts Selected situations ◼ institutions (e.g., day care centers) ◼ common source exposure (e.g., food prepared by infected food handler) Hepatitis A Prevention - Immune Globulin
Recommended doses Schedules of HAv vaccination HAVRIX③ No Doses Schedule Group Age Doses EL U*()(months) Children and adolescents 2-18 years 3 360(0.5)0,1,6-12 Adults >18 years 1,440(1.0)0,6-12 ELISA units
Group Age No. Doses EL.U.* (ml) Schedule (months) Children and adolescents 2-18 years 3 360 (0.5) 0, 1, 6-12 Adults >18 years 2 1,440 (1.0) 0, 6-12 Doses HAVRIX *ELISA units Recommended Doses & Schedules of HAV Vaccination
Hapatitis B virus 1963年 Blumberg在多次输血的血友病患者中 发现澳抗,1968年确与血清型肝炎高度相 关,1970年Dane在电镜下看到具有传染性 的42nm病毒颗粒 ■HBV在亚洲广泛流行,在中国约10%人口携 带该病毒,全球约35亿
Hapatitis B Virus ◼ 1963年Blumberg在多次输血的血友病患者中 发现澳抗，1968年确与血清型肝炎高度相 关，1970年Dane在电镜下看到具有传染性 的42nm病毒颗粒 ◼ HBV在亚洲广泛流行，在中国约10%人口携 带该病毒，全球约3.5亿
1983年将HBV及与其分子结构、生物学特性相似的土拨鼠 肝炎病毒 woodchuck hepatitis virus, WHV)、地松鼠肝炎病毒 ground squirrel hepatitis virus,GsHV及鸭肝炎病毒( luck hepatits ius,DHV归纳起来独立命名为嗜肝病毒科( Hepadnaviridae Hepadnavirus family 签6A建
◼ 1983年将HBV及与其分子结构、生物学特性相似的土拨鼠 肝炎病毒(woodchuck hepatitis virus,WHV)、地松鼠肝炎病毒 (ground squirrel hepatitis virus,GSHV)及鸭肝炎病毒(duck hepatits virus,DHV)归纳起来独立命名为嗜肝病毒科（Hepadnaviridae ）
Geographic Distribution of Chronic HBV Infection HBSAg Prevalence 8%-High 2-7%-Intermediate <2%-LoW
HBsAg Prevalence ³8% - High 2-7% - Intermediate <2% - Low Geographic Distribution of Chronic HBV Infection