Light ChainGeneFamiliesGerm line gene organizationLambdalightchain genes;n=30V2VnCCCV1Kappalightchaingenes;n=40(300)V2J1J2J3J4J5CV
Light Chain Gene Families Germ line gene organization J 1 C 1 E J 2 C 2 E J 3 C 3 E J 4 C 4 P E L V 1 P L V n P L V 2 Lambda light chain genes; n=30 P L V 1 P L V n P L V 2 J 2 J 3 J 5 C E J 1 J 4 Kappa light chain genes; n=40(300)
Light Chain GeneFamiliesGenerearrangement and expressionLVLVCLVJJJJJn00:0200000DNADNARearrangementCeHDNATranscriptionCHPrimarytranscriptRNARNAProcessingVJCmRNARNATranslationVJCProteinTransporttoERVJCProteinCV
Light Chain Gene Families Gene rearrangement and expression L V 1 L V n L V 2 J 2 J 3 J 5 J C 1 J 4 DNA P P P E P P E L V 1 L J 5 C V 2 J 4 DNA DNA Rearrangement V J C V C Protein Transport to ER Protein Translation L V J C E L V J C RNA Transcription Primary transcript RNA Processing L V J C mRNA RNA
HeavyChainGeneFamilyGerm linegeneorganizationHeavychaingenes;Vn=65(1000),Dn=27(15),J6V1V2DnVnD1D2D31L口O一ORCCCCCCCCCCH1HCH2CH3CH4Introns separate exons codingforHchaindomains
Heavy Chain Gene Family Germ line gene organization Introns separate exons coding for H chain domains Heavy chain genes; Vn=65(1000), Dn=27(15),J6 P L V1 P L Vn P L V2 D1 D2 D3 Dn C C C 3 C C 2 C 1 C 4 C 1 C 2 J 2 J 3 J 5 J1 J 4 E CH1 H CH2 CH3CH4
HeavyChainGeneFamilyGene rearrangement and expressionCCV2V1VnD1D2D3LLLHDJ rearrangementD1D2CCV1LV2VnLLHE口DNA·VDJ rearrangementV2D22CCV1JLDNATranscriptionCV2D2JCJ口RNAPrimary transcript1
Heavy Chain Gene Family Gene rearrangement and expression P L V1 P L Vn P L V2 D1 D2 D3 Dn C C J 2 J 3 J 5 J1 J 4 E DJ rearrangement P L Vn P L V1 P L V2 D2 D1 J C C 5 J 4 E DNA VDJ rearrangement D2 C C J 5 J 4 P E L V1 P L V2 DNA Transcription D2 C C J 5 J 4 E L V2 Primary transcript RNA
HeavyChainGeneFamilyGenerearrangement and expressionLV2D2JV2D2JJCCCC中-PrimarytranscriptRNAProcessingLVDJCLVDJC-AAn1mRNAformRNAforCCTranslationLVDJCLVDJCCheavyCheavychainchainTransporttoERVDJCVDJCVVCCCheavyCheavychainchain
Heavy Chain Gene Family Gene rearrangement and expression E Primary transcript E J 4 V2 D2 J C C 5 L J C C 5 L D2 J 4 V2 RNA Processing A n mRNA for C L V DJ C L V DJ C A n mRNA for C Translation C heavy chain L V DJ C L V DJ C C heavy chain Transport to ER C heavy chain V C V DJ C V DJ C C heavy chain V C