Struetural Rginforeemgrt (Folkow s Principle) Hypertensive Normotensive o0四> Contraction(%)
Importing Di Sympathetic Innervation ior yas cuhir Sirutturg in Expgrimgnsil Hypgrignsior Cerebral arteries 0.15 p<005 p<005 WKY SHR SHR. Hart ot al 1980 innervated denervated
Yasgur Sirugunil Cunssnuengss oi flypgresion Normal blood Hypertension pressure Vascular Intima hypertrophy or hyperplasia Media atrophIc Lumen vascular remodeling Wall/lumen: normal increased
ToMl Peripheral Resistanse Index as Ress and During Bicyele Exereise in Diiiergn Age Groups 5000 17-29 years 30-39 years 40-56 years 3000 2000 1000 1100 60 050010001500050010001500050010001500 vo, ml/min/m? vo, mlmin/m? vo, mumin/m? Normotensives Hypertensives LundJohansen Omvik, 1995
Forgrm Dose-Resisiintg Response Curyes to Intrarigrhl Norepinephrine 25 Hypertensives 5 20 15 Controls 10 0.2040.60.8 Siertsson, 1970 Norepinephrine(log dose og threshold dose