Allele frequencies and The hardy. Weinberg equilibrium 基因频率与 Hardy-Weinberg平衡 Ⅹ1=X12 X12=2x 22 The Hardy-Weinberg principle of genetic equilibium describes the relationship between allele frequencies and genotype frequencies under the assumption of random mating. This principle applies to loci with alleles, loci with multiple alleles, and X-linked loci
Allele frequencies and The HardyWeinberg equilibrium 基因频率与Hardy-Weinberg平衡 X11 = x1 2 X12 = 2x1x2 X22 = x2 2 The Hardy-Weinberg principle of genetic equilibium describes the relationship between allele frequencies and genotype frequencies under the assumption of random mating. This principle applies to loci with alleles, loci with multiple alleles, and X-linked loci
Random mating随机交配 这是指在群体中一种性别的任何一个个体 与其相反性别的任一个体交配的机会均等
Random mating随机交配 这是指在群体中一种性别的任何一个个体 与其相反性别的任一个体交配的机会均等
Allele frequencies in loci with multiple alleles 复等位基因的基因频率 般情况: x=xi+(1/2)>X Hardy- Weinberg平衡: X=x2,X=2
Allele frequencies in loci with multiple alleles 复等位基因的基因频率 一般情况： Hardy-Weinberg平衡： xi = Xii +(1/2) ∑Xij i≠j Xii = xi 2 , Xij = 2 xixj
Calculation of allele frequencies in random-breeding populations 随机交配群体基因频率的计算 Co-dominant or in-completed dominant alleles 等显性或不完全显性等位基因 4=(2ni+∑n:)/(2 √ Completed dominant alleles完全显性等位基因 Sex- -linked loci伴性基因频率的计算
Calculation of allele frequencies in random-breeding populations 随机交配群体基因频率的计算 ✓ Co-dominant or in-completed dominant alleles 等显性或不完全显性等位基因 xi = (2nii + ∑nij)/(2n) ✓ Completed dominant alleles 完全显性等位基因 x2 =√ nk /n ✓ Sex-linked loci 伴性基因频率的计算
For example例子 Genotype AA BB CC AB AC BC Total Observed74 0 26 1280 200 Expected720.524.51284 8—7 200 Calculate allele frequencies of A, B, c 求出等位基因A,B,C的频率
For example 例子 Calculate allele frequencies of A, B, C 求出等位基因A, B, C的频率 Genotype AA BB CC AB AC BC Total Observed 74 0 26 12 80 8 200 Expected 72 0.5 24.5 12 84 7 200