山东大学：《医学生理学 Medical Physiology》课程教学资源（PPT课件讲稿，人体生理学 Human Physiology）Chapter 1 Introduction to Physiology（主讲：刘传勇）

Section 1 Composition and Properties of the Blood Section 2 Hemostasis, Blood Coagulation and Fibrinolysis Section 3 Blood Group and Transfusion Agglutination（凝集）, hemolysis （溶血）and the transfusion reaction

I. Membrane Resting Potential II Action Potential III Initiation of Action Potential Electrophysiological Method to Record Membrane Potential I Voltage Clamp IV Local Response V Excitation and Excitability of the Tissue

I Review Structure of the Cell Membrane II Transport Through the Cell Membrane Tetrodotoxin (TTX) selectively block the voltage-gated Na+ channel ➢ Simple diffusion ➢ Ion channel ➢ Water channel Water transportation through the membrane 3 Active transport 4. Bulk Transport (Endocytosis and Excytosis)

§1 Blood coagulation Blood coagulatlon system Blood platelet §2 Anticoagulation 1. Cell reticuloendothelial system 2. Body fluid (1) antithrombin Ⅲ (AT-Ⅲ,liver): (2) Protein C (3) tissue factor pathway inhibitor (TFPI) §3 Fibrinolysis • 组成：纤维蛋白溶酶原、纤溶酶、纤溶酶原激活物与纤溶抑制物。 • 作用：使生理止血过程中所产生的局部或一过性的纤维蛋白凝块能随时溶解，从而防止血栓形成，保证血流通畅；参与组织修复、血管再生。 §4 Vascular endothelial cells VEC正常时不表达TF； VEC可生成PGI2、NO及ADP酶等物质，扩张血管、抑制血小板的活化、聚集等； VEC可产生或促进tPA、uPA等纤溶酶原激活物，促进纤溶过程； VEC的抗凝作用 • 产生TFPI、表达TM、肝素样物质

§1 Introduction • Normal function of the kidney • Renal insufficiency • Causes • Basic manifestation of renal insufficiency §2 Acute renal failure

山东大学基础医学院：《病理生理学 Pathophysiology》课程PPT教学课件（7年制）11 Respiratory Failure 呼吸衰竭

山东大学基础医学院：《病理生理学 Pathophysiology》课程PPT教学课件（7年制）09 Shock 休克

1. Basic Concepts 2. Causes 3. Classification of heart failure 4. Pathogenesis of heart failure 5. Compensatory mechanisms in heart failure 6. Functional and metabolic alterations 7. Treatment principles

Introduction Classification, etiology and pathogenesis Functional and metabolic changes Factors involved in tolerance to hypoxia Oxygen treatment and oxygen toxicity