1.吸收(Absorption) Parenteral:IV,IM,SC Oral Sublingual Sublingual Rectal Inhalation Oral N 如白 为 IM Sc TransdermaL patch Topical Inhalation Intranasal Intrathecal/lntraventricular Rectal Topical Transdermal 人凤只生名版松
1．吸收 (Absorption) The route of administration enteral parenteral Oral Sublingual Rectal IVIMSC Inhalation Intranasal Intrathecal/Intraventricular Topical Transdermal other
Administration Absorption and distribution Elimination Bile≤ A Portal Liver - Metabolites Kidney ------Urine system Oral or rectal- Gut >Faeces Percutaneous Skin Intravenous- PLASMA Breast,sweat glands Milk, 2 sweat Intramuscular Muscle 2 Brain Placenta Intrathecal--- CSF Fetus Inhalation Lung Expired air Elsevier.Rang et al:Pharmacology 6e-www.studentconsult.com 人凤只生公松
1.吸收(Absorption) 药物从给药部位进入全身循环的过程。 (1)口服给药(Oral ingestion) 吸收部位主要在小肠 ●停留时间长，经绒毛吸收面积大 ● 毛细血管壁孔道大，血流丰富 ● pH5-8,对药物解离影响小 人民口生名版松
药物从给药部位进入全身循环的过程。 (1) 口服给药 (Oral ingestion) 吸收部位主要在小肠 停留时间长，经绒毛吸收面积大 毛细血管壁孔道大，血流丰富 pH5-8，对药物解离影响小 1．吸收 (Absorption)
Fick扩散律 (Fick's Law of Diffusion) 面积×通透系数 流量（单位时间分子数）三 厚度 胃肠道各部位吸收面积(m2) 肠腔 ●口腔 0.5-1.0 s。小肠 。直肠 0.02 got ·胃 0.1-0.2 ● 小肠 100 ·大肠 小肠壁片段 0.04-0.07 绒毛 人凤只生公版松
胃肠道各部位吸收面积(m 2) 口腔 0.5-l .0 直肠 0.02 胃 0.1-0.2 小肠 100 大肠 0.04-0.07 Fick扩散律 （Fick’s Law of Diffusion ） 流量 (单位时间分子数) = 面积 通透系数 厚度
Factors affecting rate of gastra- intestinal absorption (1)gastro-intestinal pH; (2)gastro-intestinal motility; (3)gastro-intestinal blood flow (4)physico-chemical interaction with gut content; (5)various pharmaceutical preparations; (6)different administration routes of drugs and so on. 人凤只生B版松
Factors affecting rate of gastraintestinal absorption (1) gastro-intestinal pH; (2) gastro-intestinal motility; (3) gastro-intestinal blood flow ; (4) physico-chemical interaction with gut content; (5) various pharmaceutical preparations; (6) different administration routes of drugs and so on