Medical Genetics Euchromatin is threadlike, delicate. It is most abundant in active, transcribing cells. Thus the presence of euchromatin is significant because the regions of DNA to be transcribed or duplicated must uncoil before the genetic code can be read
Medical Genetics Euchromatin is threadlike, delicate. It is most abundant in active, transcribing cells. Thus, the presence of euchromatin is significant because the regions of DNA to be transcribed or duplicated must uncoil before the genetic code can be read
Medical Genetics Condensation and decondensation of the dna are at least partiall reversible processes Each DNA segment that has to be replicated or transcribed has to be decondensed during this time
Medical Genetics Condensation and decondensation of the DNA are at least partially reversible processes. Each DNA segment that has to be replicated or transcribed has to be decondensed during this time
Medical Genetics The highest degree of condensation can be found in the chromosomes(mitosis, meiosis) during cell division
Medical Genetics The highest degree of condensation can be found in the chromosomes (mitosis, meiosis) during cell division
Medical Genetics Chromatin fibers 30 nm 11 nm chromatin fiber ( beads) DNA charged N termini nucleosome highly acetylated (bind DNA on neigboring core histones nucleosomes (especially H3 and H4) the solenoid HIGH level of histone H1 Reduced level of histone h1 No gene transcription Gene transcription possible 10989
Medical Genetics
Medical Genetics Chromatosome c Core histone octamer+1 linker Histone+2 fill tu rms of DAA (168 bp) H1 H3 H3 1 mM 803 5mMA:rB0 Linker histone and histone termini control linker DNA entry/exit of chromatosome in chromatin fiber
Medical Genetics